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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients
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Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients

机译：路易体和阿尔茨海默氏病患者痴呆程度与痴呆严重程度与行为和心理症状的关系

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Background/Aims: Behavioral and psychological symptoms of dementia (BPSD) are common in the clinical manifestation of dementia. Although most patients with dementia exhibit some BPSD during the course of the illness, the association of BPSD with the stage of dementia remains unclear. It was the aim of this study to evaluate the impact of severity of dementia on the expression of BPSD in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Methods: Ninety-seven patients with DLB and 393 patients with AD were recruited from 8 dementia clinics across Japan. BPSD were assessed by the Neuropsychiatric Inventory (NPI). A relationship between BPSD and dementia stage classified by the Clinical Dementia Rating (CDR) in each type of dementia was assessed. Results: No significant difference was seen in NPI total score across CDR staging in the DLB group. On the other hand, the NPI total score significantly increased with dementia stage in the AD group. Conclusion: The relationship of dementia stage with the expression of BPSD was different according to the type of dementia. BPSD and dementia stage were correlated in AD subjects, in whom psychiatric symptoms increase as the disease progresses, but not in DLB subjects.
机译：背景/目的：痴呆的行为和心理症状（BPSD）在痴呆的临床表现中很常见。尽管大多数痴呆患者在疾病过程中表现出一些BPSD，但尚不清楚BPSD与痴呆阶段的关系。这项研究的目的是评估路易氏体（DLB）和阿尔茨海默氏病（AD）痴呆患者的痴呆严重程度对BPSD表达的影响。方法：从日本全国8家痴呆诊所招募了97名DLB患者和393名AD患者。 BPSD由神经精神病学调查表（NPI）评估。评估了每种类型的痴呆中按临床痴呆评分（CDR）分类的BPSD与痴呆阶段之间的关系。结果：DLB组的CDR分期中NPI总分无明显差异。另一方面，AD组的痴呆阶段的NPI总得分显着增加。结论：根据痴呆类型的不同，痴呆阶段与BPSD表达的关系也不同。 BPSD和痴呆阶段在AD受试者中相关，在AD受试者中，精神症状随着疾病的进展而增加，而在DLB受试者中则不相关。

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