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首页> 外文期刊>Journal of Epilepsy and Clinical Neurophysiology >Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?
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Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?

机译：患有或未患有癫痫发作的MTLE患者之间MT-I / II的水平不同：海马MT-I / II是否会影响癫痫发作的传播，或者癫痫发作会促进MT-I / II的差异表达？

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摘要

In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) were evaluated for expression of MT-I/II and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis and reduced neuronal population. MT-I/II levels did not correlate with any clinical variables, but patients with secondary generalized seizures (SGS) had less MT-I/II than patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from MTLE patients and our data suggest that it may be associated with different seizure spread patterns.
机译：在中枢神经系统中，锌在神经传递过程中会与谷氨酸一起释放，并且过量会促进神经元死亡。实验研究表明，螯合游离锌的金属硫蛋白I / II（MT-I / II）可以影响癫痫发作并降低癫痫持续状态后神经元的死亡。我们的目的是评估颞叶癫痫（TLE）患者海马中MT-I / II的表达。评价了具有药物抗性的颞叶颞叶癫痫（MTLE）患者的海马的MT-I / II表达以及神经元，星形胶质和小胶质细胞的表达。与对照组相比，MTLE组的MT-I / II表达，星形胶质增生和神经元数量减少均表现出广泛的增长。 MT-I / II水平与任何临床变量均无相关性，但继发性全身性癫痫（SGS）患者的MT-I / II含量低于无SGS的患者。总之，MTLE患者海马中MT-I / II表达增加，我们的数据表明它可能与不同的癫痫发作模式有关。

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