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首页> 外文期刊>Journal of Epithelial Biology & Pharmacology >Tear Film and Ocular Surface Surfactants
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Tear Film and Ocular Surface Surfactants

机译：泪膜和眼表表面活性剂

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The hydrophobic surfactant proteins B (SP-B) and C (SP-C) are tightly bound to phospholipids. These proteins play important roles in maintaining the surface tension-lowering properties of pulmonary surfactant. Surfactant protein A (SP-A) and D (SP-D) are extremely hydrophilic and are thought to have a role in recycling surfactant and especially in improving host defense in the lung. Moreover, SP-A supports the hydrophobic surfactant proteins during surfactant subtype assembly and inhibits secretion of lamellar bodies into the alveolar space. During recent years surfactant proteins have also been detected at locations outside the lung such as the lacrimal apparatus. In this review, the latest information regarding SP function and regulation in the human lacrimal system, the tear film and the ocular surface is summarized with regard to mucous epithelial integrity, rheological and antimicrobial properties of the tear film, tear outflow, certain disease states and possible therapeutic perspectives.
机译：疏水性表面活性剂蛋白B（SP-B）和C（SP-C）与磷脂紧密结合。这些蛋白质在维持肺表面活性剂的降低表面张力的性质中起重要作用。表面活性剂蛋白A（SP-A）和D（SP-D）具有极强的亲水性，被认为在回收表面活性剂，尤其是改善肺部宿主防御方面具有作用。此外，SP-A在表面活性剂亚型装配过程中支持疏水性表面活性剂蛋白，并抑制片状体向肺泡腔内的分泌。近年来，还已经在肺外诸如泪器的位置检测到表面活性剂蛋白。在这篇综述中，关于粘膜上皮的完整性，泪膜的流变和抗菌特性，泪液流出，某些疾病和可能的治疗观点。

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