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首页> 外文期刊>Journal of Epithelial Biology & Pharmacology >Role of Airway Epithelium-Origin Chemokines and their Receptors in COPD
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Role of Airway Epithelium-Origin Chemokines and their Receptors in COPD

机译：气道上皮-原始趋化因子及其受体在COPD中的作用

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Chronic obstructive pulmonary disease (COPD) is characterized with the chronic airway inflammation associated with progressive obstruction of airflow. Airway epithelial cells play an essential role of development in COPD. Chemokines as extracellular signaling proteins have been suggested to be involved in the inflammatory process of COPD. The present review summarized the variation of chemokines in the airway epithelium of COPD patients and discussed the potential roles of chemokines in the pathogenesis of COPD. Increased level of IL-8 was considered as a key and unique chemokine in the initiation and progress of COPD. Others like CXCR3 chemokines and eosinophils-related chemokines should be also considered. Further research will be necessary to explore whether targeting on these chemokines, particularly IL-8 and CXCRs, can be benefit to patients with COPD. It is also important to identify and validate a critical and specific chemokine with differential diagnostic value. The correlation of chemokines with disease severity, diagnosis and therapy in COPD should be further clarified. High-throughout technologies, e.g. genomics, proteomics and bioinformatics, can be more attractive approaches to validate the importance of chemokines in the disease. Although the exact role of chemokines in the pathogenesis of COPD still needs to be explored, anti-chemokines or receptor antagonists may be an alterative of new therapies for patients with COPD.
机译：慢性阻塞性肺疾病（COPD）的特征是与气流进行性阻塞相关的慢性气道炎症。气道上皮细胞在COPD的发展中起着至关重要的作用。已经提出趋化因子作为细胞外信号转导蛋白参与了COPD的炎症过程。本文综述了COPD患者气道上皮中趋化因子的变化，并探讨了趋化因子在COPD发病中的潜在作用。 IL-8水平升高被认为是COPD发生和发展的关键和独特的趋化因子。还应该考虑其他类似CXCR3趋化因子和嗜酸性粒细胞相关的趋化因子。有必要进行进一步的研究，以探索针对这些趋化因子，尤其是IL-8和CXCR的药物是否可以使COPD患者受益。鉴定和验证具有鉴别诊断价值的关键和特异性趋化因子也很重要。应进一步阐明趋化因子与COPD疾病严重程度，诊断和治疗的相关性。高通量技术，例如基因组学，蛋白质组学和生物信息学可能是验证趋化因子在疾病中的重要性的更具吸引力的方法。尽管仍需要探讨趋化因子在COPD发病机理中的确切作用，但抗趋化因子或受体拮抗剂可能是COPD患者新疗法的替代方案。

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