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首页> 外文期刊>Journal of Clinical Immunology >Chemokines and chemokine receptors: their role in allergic airway disease.
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Chemokines and chemokine receptors: their role in allergic airway disease.

机译：趋化因子和趋化因子受体：它们在过敏气道疾病中的作用。

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One of the hallmarks of allergic pulmonary disorders is the accumulation of an abnormally large number of leukocytes including eosinophils, neutrophils, lymphocytes, basophils, and macrophages in the lung. There is now substantial evidence that eosinophils, under the control of T lymphocytes, are major effector cells in the pathogenesis of asthma. Therefore, understanding the mechanisms by which eosinophils accumulate and are activated in tissues is a fundamental question very relevant to allergic diseases. Another characteristic of allergic inflammation is the activation of leukocytes resulting in the release of biologically active mediators, such as histamine from mast cells and basophils. It is now apparent that chemokines are potent leukocyte chemoattractants, cellular activating factors, histamine releasing factors, and regulators of homeostatic immunity, making them particularly important in the pathogenesis of airway inflammation in asthma. In this regard, chemokines are attractive new therapeutic targets for the treatment of allergic disease. This article focuses on recently emerging data on the importance of chemokines and their receptors in allergic airway inflammation.
机译：过敏性肺疾病的标志之一是在肺中累积嗜酸性粒细胞，中性粒细胞，淋巴细胞，嗜碱性粒细胞和肺中巨噬细胞的异常大量白细胞的积累。现在存在实质性证据，即嗜酸性粒细胞在T淋巴细胞的控制下是哮喘发病机制中的主要效应细胞。因此，理解嗜酸性粒细胞积聚并在组织中激活的机制是与过敏性疾病非常相关的基本问题。过敏性炎症的另一种特征是活化白细胞，导致生物活性介质的释放，例如来自肥大细胞和嗜碱性粒细胞的组胺。显而易见的是，趋化因子是有效的白细胞化疗，细胞活化因子，组胺释放因子和稳态免疫调节因子，使它们在哮喘中气道炎症的发病机制中特别重要。在这方面，趋化因子是用于治疗过敏性疾病的新治疗靶标。本文侧重于最近出现了关于趋化因子及其在过敏气道炎症中的受体的重要性数据。

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