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首页> 外文期刊>Journal of Epithelial Biology & Pharmacology >Epithelial Barrier Leak in Gastrointestinal Disease and Multiorgan Failure
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Epithelial Barrier Leak in Gastrointestinal Disease and Multiorgan Failure

机译：胃肠道疾病和多器官衰竭的上皮屏障泄漏

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There are a myriad of clinical conditions whose disease etiology involves leakiness of an epithelial and/orendothelial barrier. To underscore the medical usefulness of agents that can augment barrier function, the theme ofthis special issue, two disease areas are highlighted. The first is the phenomenon of “leaky gut” which can play relativelyobvious roles in gastrointestinal diseases such as celiac disease, Crohn’s disease, and ulcerative colitis. It may playless obvious roles in seemingly unrelated illnesses such as autism, diabetes and certain microbial infectious diseases.A second disease area where barrier compromise plays a major role is multi-organ failure, a major cause of death inICUs. Multi-organ failure highlights the important effect that the immune system and oxidative stress can have on barrierelements. The use of barrier enhancing and protecting agents in nutritional feeding in ICUs should be an area of intenseinterest in the future.
机译：有无数的临床情况，其病因涉及上皮和/或内皮屏障的渗漏。为了强调可以增强屏障功能的药物的医学实用性，本期特刊的主题是两个疾病领域。首先是“漏肠”现象，在胃肠道疾病如腹腔疾病，克罗恩病和溃疡性结肠炎中起相对明显的作用。在自闭症，糖尿病和某些微生物感染性疾病等看似无关的疾病中，它可能起着不明显的作用。屏障损害起主要作用的第二个疾病领域是多器官衰竭，这是ICU的主要死亡原因。多器官衰竭突显了免疫系统和氧化应激对屏障元素的重要影响。在重症监护病房的营养喂养中使用屏障增强和保护剂应该是未来引起人们极大关注的领域。

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