• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Epithelial Biology & Pharmacology >Enhancement of Renal Tubular Epithelial Cell Barrier Function by the Immunosuppressant Drugs Cyclosporine A and Sirolimus
【24h】

Enhancement of Renal Tubular Epithelial Cell Barrier Function by the Immunosuppressant Drugs Cyclosporine A and Sirolimus

机译：免疫抑制剂环孢菌素A和西罗莫司增强肾小管上皮细胞屏障功能

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The primary function of the kidney includes the elimination of waste products and the maintenance of fluid andelectrolyte composition of the body. The functioning unit of the kidney is the nephron including the glomerulus with afiltration function and the tubule with a reabsorption and secretion function. The fluid and electrolyte homeostasis isachieved largely through selective, vectorial transport facilitated by the renal tubular epithelium. This involves both transcellularand paracellular transport. Paracellular transport across renal tubular epithelial tight junctions (TJs) varies in differentparts of the nephron. The relative concentrations of different claudins that are located in the TJ at any time determinethe ion and size selectivity of the paracellular diffusion pathway in the kidney as in other tissues. In this article, wereview work from our own laboratory and others providing evidence that immunosuppressive drugs, especially cyclosporineA (CsA) and sirolimus (SRL) and can alter transport molecules in kidney tubules. We outline evidence that CsA and SRLcan enhance renal epithelial barrier function as indicated by transepithelial electrical resistance (TEER). The possiblesignalling mechanisms involved in altering the TJs and claudins by CsA and SRL are outlined and involve both TGF-β1and the ERK 1/2. These effects of CsA and SRL on kidney epithelia cell barrier function may help to explain some of therenal transport defects and nephrotoxicity seen with CsA and SRL. However if similar effects occur systemically in vivo,with these two immunosuppressive drugs, the enhancement of barrier function in areas of the body may decrease luminalantigen presentation, decreasing immune activation and support the immunosuppressive action of these drugs.
机译：肾脏的主要功能包括消除废物和维持人体的液体和电解质成分。肾脏的功能单位是肾小球，包括具有滤过功能的肾小球和具有重吸收和分泌功能的肾小管。液体和电解质的体内平衡主要是通过肾小管上皮促进的选择性矢量运输来实现的。这涉及跨细胞和旁细胞运输。跨肾小管上皮紧密连接（TJs）的细胞旁运输在肾的不同部分有所不同。在任何时候，位于TJ中的不同claudin的相对浓度决定了肾中副细胞扩散途径的离子和大小选择性，就像在其他组织中一样。在本文中，来自我们自己实验室和其他实验室的研究工作提供了证据，证明免疫抑制药物，尤其是环孢菌素A（CsA）和西罗莫司（SRL）可以改变肾小管中的转运分子。我们概述了证据，如经上皮电阻（TEER）所示，CsA和SRL可以增强肾上皮屏障功能。概述了可能由CsA和SRL改变TJ和claudins的信号机制，并涉及TGF-β1和ERK 1/2。 CsA和SRL对肾脏上皮细胞屏障功能的这些作用可能有助于解释CsA和SRL所见的一些局部运输缺陷和肾毒性。但是，如果使用这两种免疫抑制药物在体内全身发生相似的作用，则在人体区域中屏障功能的增强可能会降低腔内抗原呈递，降低免疫激活并支持这两种药物的免疫抑制作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号