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首页> 外文期刊>Journal of Epilepsy and Clinical Neurophysiology >Effect of aerobic physical exercise in pinealectomized animals submitted to the pilocarpine model of epilepsy
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Effect of aerobic physical exercise in pinealectomized animals submitted to the pilocarpine model of epilepsy

机译：有氧体育锻炼对毛果芸香碱癫痫模型的松果体切除动物的影响

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OBJECTIVE: To better clarify the positive effects of physical exercise in the epilepsy, we analyzed the effect of the pinealectomy in animals with temporal lobe epilepsy (TLE) induced by pilocarpine submitted to an aerobic physical program. MATERIAL AND METHODS: Forty adults Wistar rats were used: 1) PX + CHRONIC - Pinealectomized animals (PX) with TLE (CHRONIC) without exercise (n = 9); 2) PX + CHRONIC + EXERCISE - submitted to an aerobic physical exercise program (n = 5); 3) CHRONIC - without exercise (n = 8); 4) CHRONIC + EXERCISE (n = 8); 5) CTRL - control without exercise (n = 5); 6) CTRL + EXERCISE (n = 5). The physical exercise program consisted of 1 hour of treadmill, 5 days/week, during 30 days, at 60% VO2max. The Nissl and neo-Timm methods were used. RESULTS: The pinealectomy increased the frequency of seizures in animals with epilepsy. It was observed a reduction of the neuronal death and mossy fiber sprouting in the animals with epilepsy submitted to an aerobic physical exercise program. However, the physical exercise program did not modify the frequency of the seizures in the pinealectomized animals.
机译：目的：为了更好地阐明体育锻炼在癫痫中的积极作用，我们分析了松果体切除术对接受有氧体育锻炼的毛果芸香碱诱发的颞叶癫痫（TLE）的动物的影响。材料与方法：使用40只成年Wistar大鼠：1）PX +慢性-松散性切除术的动物（PX）有TLE（慢性）（n = 9）; 2）PX +慢性+锻炼-提交有氧体育锻炼计划（n = 5）; 3）慢性-不做运动（n = 8）; 4）慢性+锻炼（n = 8）; 5）CTRL-无运动控制（n = 5）; 6）CTRL +锻炼（n = 5）。体育锻炼程序包括跑步机1个小时，每周5天，每天30天，最大摄氧量为60％。使用了Nissl和neo-Timm方法。结果：松果体切除术增加了癫痫动物的癫痫发作频率。观察到在进行有氧体育锻炼的癫痫动物中神经元死亡和苔藓纤维发芽的减少。但是，体育锻炼程序并未改变松果体切除动物的癫痫发作频率。

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