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首页> 外文期刊>Journal of genetics >Association of interleukin-10 (A$_{10}8_{2}$G) gene polymorphism with oral squamous cell carcinoma in north Indian population
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Association of interleukin-10 (A$_{10}8_{2}$G) gene polymorphism with oral squamous cell carcinoma in north Indian population

机译：白细胞介素10（A $ _ {10} 8_ {2} $ G）基因多态性与印度北部人群口腔鳞状细胞癌的关联

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The functional polymorphism A1082G in the gene (IL10) for interleukin-10 associated with risk of oral squamous cell car-cinoma (OSCC). The present casea€“control study was to evaluate the possible association between IL10 A1082G gene and OSCC in north Indian population. Analysis ofIL10 A1082G genotype in 232 OSCC cases and 221 healthy controls of comparable age, gender, smokers, tobacco chewing and alcohol consumption.IL10 A1082G status in cases and controls were evaluated by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The frequencies ofIL10 A1082G polymorphism AA,AG,GG genotypes were 29.74, 68.10 and 2.15% in OSCC cases and 57.46, 42.08 and 0.45% inhealthy controls. The average frequency of G mutant allele was 36.20% in OSCC cases compared with 21.50% among the controls and this allele was associated with increased risk for OSCC cases. HeterozygousAG genotype was found statistically significant in OSCC cases than in controls (OR = 1.6, 95% CI=1.1a€“2.2,P=0.003), whereas homozygous mutantGG genotype was not found significant (OR =4.7, 95% CI=0.55a€“41.1,P= 0.2). Moreover, we found that G allele was significantin OSCC cases of tobacco chewing. The frequency of IL10A1082G polymorphism G allele and AG genotype is associated with OSCC cases as compared with controls; this may be due to smoking and tobacco chewing. Our findings showed that inIL10 A1082G gene polymorphism AG genotype and G allele may participate in the progression of OSCC
机译：IL-10基因（IL10）中的功能性多态性A1082G与口腔鳞状细胞癌（OSCC）的风险有关。本病例的对照研究旨在评估印度北部人群中IL10 A1082G基因与OSCC之间的可能联系。分析232例OSCC患者和221名年龄，性别，吸烟者，咀嚼烟草和饮酒的健康对照组中IL10 A1082G基因型。通过聚合酶链反应和限制性片段长度多态性（PCR-RFLP）评估病例和对照组中IL10 A1082G的状态。 IL10 A1082G多态性AA，AG，GG基因型的频率在OSCC病例中分别为29.74、68.10和2.15％，在健康对照组中为57.46、42.08和0.45％。在OSCC病例中，G突变等位基因的平均频率为36.20％，而在对照组中为21.50％，该等位基因与OSCC病例风险增加相关。发现OSCC病例中杂合AG基因型比对照组具有统计学意义（OR = 1.6，95％CI =1.1a≤2.2，P = 0.003），而纯合突变体GG基因型则没有显着意义（OR = 4.7，95％CI = 0.55）。 a“ 41.1，P ＝ 0.2）。此外，我们发现G等位基因在OSCC烟草咀嚼病例中很重要。与对照组相比，IL10A1082G多态性G等位基因和AG基因型的频率与OSCC病例相关。这可能是由于吸烟和咀嚼烟草引起的。我们的发现表明inIL10 A1082G基因多态性AG基因型和G等位基因可能参与了OSCC的进程

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