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首页> 外文期刊>Journal of genetics >A genome scan for quantitative trait loci affecting average daily gain and Kleiber ratio in Baluchi Sheep
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A genome scan for quantitative trait loci affecting average daily gain and Kleiber ratio in Baluchi Sheep

机译：基因组扫描对定量特征性状基因座的影响

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Genomewide association study (GWAS) is an efficient tool for the detection of SNPs and candidate genes in quantitative traits.Growth rate is an important trait for increasing themeat production in sheep. A total of 96 Baluchi sheep were genotyped using Illumina OvineSNP50 BeadChip to run a GWAS for an average daily gain (ADG) and Kleiber ratio (KR) traits in different periods of age in sheep. Traits included were average daily gain from birth to three months (ADG0a??3), from three months to six months (ADG3a??6), fromsix months to nine months(ADG6a??9), fromnine months to yearling (ADG9a??12), frombirth to six months (ADG0a??6),from three months to nine months (ADG3a??9), from threemonths to yearling (ADG3a??12) and corresponding Kleiber ratios (KR0a??3, KR3a??6, KR6a??9, KR9a??12, KR0a??6, KR3a??9 and KR3a??12, respectively). A total of 42,243 SNPs passed the quality-control filters and were analysed by PLINK software in a linear mixed model. Two SNPs were identified on two chromosomes at the 5% genomewidesignificance level for KR(3a??9) and KR(6a??9). Two candidate genes, namely MAGI1 and ZNF770, were identified correspondingly harbouring and close to these QTL. Also, a total of 21 SNPs were found on chromosomes 2, 3, 5, 6, 7, 10, 17, 19, 20 and 25 at the 5% chromosomewide significance level for ADG and KR traits. Thus, we suggest more studies to discover the causative variants for growth traits in sheep.
机译：全基因组关联研究（GWAS）是检测数量性状中SNP和候选基因的有效工具。生长速率是增加绵羊主题生产的重要性状。使用Illumina OvineSNP50 BeadChip对总共96头Bal路支羊进行基因分型，以运行GWAS进行不同年龄段绵羊的平均日增重（ADG）和Kleiber比率（KR）性状。性状包括从出生到三个月的平均日增重（ADG0a ?? 3），从三个月到六个月的平均日增重（ADG3a ?? 6），从六个月到九个月的平均日增重（ADG6a ?? 9），从九个月到一岁（ADG9a？从出生到六个月（ΔG0aΔβ6），从三个月到九个月（ADG3aΔβ9），从三个月到一岁（ADG3aΔβ12）以及相应的Kleiber比率（KR0aΔβ3，KR3aΔβ），Δ12）。分别为α6，KR6aα9，KR9aα12，KR0aα6，KR3aα9和KR3aα12。共有42,243个SNP通过了质量控制过滤器，并通过PLINK软件在线性混合模型中进行了分析。在KR（3aΔ9）和KR（6aΔ9）的5％基因组有显着性水平的两条染色体上鉴定出两个SNP。鉴定出两个候选基因，分别为MAGI1和ZNF770，它们隐匿并靠近这些QTL。另外，在2、3、5、6、7、10、17、19、20和25号染色体上，在ADG和KR性状的5％染色体显着性水平上共发现21个SNP。因此，我们建议进行更多的研究以发现绵羊生长性状的致病变异。

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