...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of genetics >A genome scan for quantitative trait loci affecting average daily gain and Kleiber ratio in Baluchi Sheep
【24h】

A genome scan for quantitative trait loci affecting average daily gain and Kleiber ratio in Baluchi Sheep

机译：用于量化性状基因座的基因组扫描，影响Baluchi绵羊平均每日增益和瘢痕杆比率的基因座

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Genomewide association study (GWAS) is an efficient tool for the detection of SNPs and candidate genes in quantitative traits. Growth rate is an important trait for increasing the meat production in sheep. A total of 96 Baluchi sheep were genotyped using Illumina OvineSNP50 BeadChip to run a GWAS for an average daily gain (ADG) and Kleiber ratio (KR) traits in different periods of age in sheep. Traits included were average daily gain from birth to three months (ADG(0-3)), from three months to six months (ADG(3-6)), from six months to nine months (ADG(6-9)), from nine months to yearling (ADG(9-12)), from birth to six months (ADG(0-6)), from three months to nine months (ADG(3-9)), from three months to yearling (ADG(3-12)) and corresponding Kleiber ratios (KR9-3, KR3-6, KR6-9, KR9-12, KR0-6, KR(3-9)and KR3-12, respectively). A total of 42,243 SNPs passed the quality-control filters and were analysed by PLINK software in a linear mixed model. Two SNPs were identified on two chromosomes at the 5% genomewide significance level for KR(3-9) and KR(6-9). Two candidate genes, namely MAGI1 and ZNF770, were identified correspondingly harbouring and close to these QTL. Also, a total of 21 SNPs were found on chromosomes 2, 3, 5, 6, 7, 10, 17, 19, 20 and 25 at the 5% chromosomewide significance level for ADG and KR traits. Thus, we suggest more studies to discover the causative variants for growth traits in sheep.
机译：基因组结合研究（GWAS）是一种有效的用于在定量性状中检测SNP和候选基因的有效工具。增长率是增加绵羊肉类生产的重要特征。使用Illumina Ovinesnp50 Beadchip进行了总共96个Baluchi绵羊，以在绵羊不同时期的平均每日增益（ADG）和Kleiber比率（KR）特征的情况下进行GWA。包括从出生到三个月的平均每日收益（ADG（0-3）），从三个月到六个月（ADG（3-6）），从六个月到九个月（ADG（6-9）），从九个月到七个月（ADG（9-12）），从出生到六个月（ADG（0-6）），从三个月到九个月（ADG（3-9）），从三个月到七岁（ADG （3-12））和相应的Kleiber比（KR9-3，KR3-6，KR6-9，KR9-12，KR0-6，KR（3-9）和KR3-12分别）。共使用42,243个SNP通过质量控制过滤器，并通过PLINK软件进行分析在线性混合模型。在kr（3-9）和Kr（6-9）的5％基因组显着性水平上，在两种染色体上鉴定了两个SNP。相应地讨论了两个候选基因，即Magi1和ZnF770，相应地覆盖并接近这些QTL。此外，在ADG和KR特征的5％染色体显着性水平下，共发现总共21个SNP。因此，我们建议更多的研究以发现羊在绵羊中生长性状的致病变体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号