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首页> 外文期刊>Journal of Experimental Neuroscience >Molecular Mechanisms Directing Spine Outgrowth and Synaptic Partner Selection in Caenorhabditis elegans:
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Molecular Mechanisms Directing Spine Outgrowth and Synaptic Partner Selection in Caenorhabditis elegans:

机译：在秀丽隐杆线虫中指导脊柱生长和突触伙伴选择的分子机制：

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The development of the nervous system requires precise outgrowth, extension, and wiring of both axons and dendrites to generate properly functioning neural circuits. The molecular mechanisms that shape neurite development, in particular dendritic development, remain incompletely understood. Dendrites are often highly branched and coated with actin-filled, thorny protrusions, called dendritic spines, that allow for increased numbers of synaptic contacts with neighboring neurons. Disruptions in dendritic spine development have been implicated in many neurological disorders such as autism, schizophrenia, and Alzheimer’s disease. Although the development of dendritic spines is vital for cognitive function, understanding the mechanisms driving their outgrowth and stabilization in vivo remains a challenge. Our recent work identifies the presence of dendritic spine-like structures in the nematode Caenorhabditis elegans and provides initial insights into mechanisms promoting spine outgrowth in this system. Specifically, we show that neurexinrx-1 is a critical molecular component in directing the development of synaptic connections and promoting spine outgrowth. Our investigation provides important insights into the molecular machinery that sculpt synaptic connectivity, and continuing efforts in this system offer the potential for identifying new mechanisms governing both synaptic partner selection and dendritic spine outgrowth.
机译：神经系统的发育需要轴突和树突的精确向外生长，延伸和布线，以生成功能正常的神经回路。形成神经突发展，特别是树突状发展的分子机制仍不完全了解。树突通常高度分支，并覆盖有肌动蛋白填充的棘手突起，称为树突棘，可增加与邻近神经元的突触接触数量。树突棘发育受阻与许多神经系统疾病有关，例如自闭症，精神分裂症和阿尔茨海默氏病。尽管树突棘的发育对于认知功能至关重要，但了解驱动其在体内生长和稳定的机制仍然是一个挑战。我们最近的工作确定了线虫秀丽隐杆线虫中树突状脊柱状结构的存在，并提供了在该系统中促进脊柱生长的机制的初步见解。具体来说，我们显示神经毒素/ nrx-1是指导突触连接的发展和促进脊柱生长的关键分子成分。我们的研究为雕刻突触连通性的分子机制提供了重要的见识，并且在该系统中的不断努力提供了识别控制突触伴侣选择和树突棘生长的新机制的潜力。

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