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首页> 外文期刊>Journal of Experimental Neuroscience >Salt an Essential Nutrient: Advances in Understanding Salt Taste Detection Using Drosophila as a Model System:
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Salt an Essential Nutrient: Advances in Understanding Salt Taste Detection Using Drosophila as a Model System:

机译：盐是必需营养素：使用果蝇作为模型系统了解盐味检测的进展：

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摘要

Taste modalities are conserved in insects and mammals. Sweet gustatory signals evoke attractive behaviors while bitter gustatory information drive aversive behaviors. Salt (NaCl) is an essential nutrient required for various physiological processes, including electrolyte homeostasis, neuronal activity, nutrient absorption, and muscle contraction. Not only mammals, even in Drosophila melanogaster, the detection of NaCl induces two different behaviors: Low concentrations of NaCl act as an attractant, whereas high concentrations act as repellant. The fruit fly is an excellent model system for studying the underlying mechanisms of salt taste due to its relatively simple neuroanatomical organization of the brain and peripheral taste system, the availability of powerful genetic tools and transgenic strains. In this review, we have revisited the literature and the information provided by various laboratories using invertebrate model system Drosophila that has helped us to understand NaCl salt taste so far. We hope that this compiled information from Drosophila will be of general significance and interest for forthcoming studies of the structure, function, and behavioral role of NaCl-sensitive (low and high concentrations) gustatory circuitry for understanding NaCl salt taste in all animals.
机译：在昆虫和哺乳动物中，味道模式得以保留。甜味的味觉信号唤起诱人的行为，而苦味的味觉信息推动厌恶行为。盐（NaCl）是各种生理过程所需的必要营养素，包括电解质稳态，神经元活动，营养素吸收和肌肉收缩。不仅哺乳动物，甚至在黑腹果蝇中，检测到的NaCl也会引起两种不同的行为：低浓度的NaCl充当引诱剂，而高浓度的NaCl充当驱避剂。果蝇由于其相对简单的大脑和周围味觉系统的神经解剖结构，强大的遗传工具和转基因菌株的可用性，因此是研究盐味潜在机制的极佳模型系统。在这篇综述中，我们使用无脊椎动物模型系统果蝇（Drosophila）重新审视了各个实验室提供的文献和信息，该系统迄今已帮助我们了解了氯化钠盐的味道。我们希望从果蝇收集到的这些信息将对即将开展的有关NaCl敏感（低浓度和高浓度）味觉电路的结构，功能和行为作用的研究具有一般意义和兴趣，以了解所有动物的NaCl盐味。

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