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首页> 外文期刊>Journal of Ginseng Research >Effect of Korean Red Ginseng extracts on drug-drug interactions
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Effect of Korean Red Ginseng extracts on drug-drug interactions

机译：韩国红参提取物对药物相互作用的影响

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Background: Ginseng has been the subject of many experimental and clinical studies to uncover thediverse biological activities of its constituent compounds. It is a traditional medicine that has been usedfor its immunostimulatory, antithrombotic, antioxidative, anti-inflammatory, and anticancer effects.Ginseng may interact with concomitant medications and alter metabolism and/or drug transport, whichmay alter the known efficacy and safety of a drug; thus, the role of ginseng may be controversial whentaken with other medications.Methods: We extensively assessed the effects of Korean Red Ginseng (KRG) in rats on the expression ofenzymes responsible for drug metabolism [cytochrome p450 (CYP)] and transporters [multiple drugresistance (MDR) and organic anion transporter (OAT)] in vitro and on the pharmacokinetics of two probedrugs, midazolam and fexofenadine, after a 2-wk repeated administration of KRG at different doses.Results: The results showed that 30 mg/kg KRG significantly increased the expression level of CYP3A11protein in the liver and 100 mg/kg KRG increased both the mRNA and protein expression of OAT1 in thekidney. Additionally, KRG significantly increased the mRNA and protein expression of OAT1, OAT3, andMDR1 in the liver. Although there were no significant changes in the metabolism of midazolam to itsmajor metabolite, 10-hydroxymidazolam, KRG significantly decreased the systemic exposure of fexofenadinein a dose-dependent manner.Conclusion: Because KRG is used as a health supplement, there is a risk of KRG overdose; thus, a clinicaltrial of high doses would be useful. The use of KRG in combination with P-glycoprotein substrate drugsshould also be carefully monitored.
机译：背景：人参一直是许多实验和临床研究的主题，以揭示其成分的多种生物活性。它是一种传统药物，具有免疫刺激，抗血栓形成，抗氧化，抗炎和抗癌作用。人参可能与伴随药物相互作用，并改变新陈代谢和/或药物运输，这可能会改变药物的已知功效和安全性;方法：我们广泛评估了韩国红参（KRG）在大鼠中对负责药物代谢酶[细胞色素p450（CYP）]和转运蛋白[多种耐药性]表达的影响。 （MDR）和有机阴离子转运蛋白（OAT）]的体外研究，以及在连续2周重复不同剂量的KRG给药后，两种探针药物（咪达唑仑和非索非那定）的药代动力学。结果：结果表明，30 mg / kg KRG显着CYP3A11蛋白在肝脏中的表达水平升高，而100 mg / kg KRG增加肾脏中OAT1的mRNA和蛋白表达。此外，KRG显着增加了肝脏中OAT1，OAT3和MDR1的mRNA和蛋白表达。尽管咪达唑仑为其主要代谢物10-羟基咪达唑仑的代谢没有显着变化，但KRG以剂量依赖的方式显着降低了非索非那定的全身暴露量。结论：由于KRG被用作健康补充剂，因此存在KRG的风险过量;因此，高剂量的临床试验将是有用的。还应仔细监测KRG与P-糖蛋白底物药物联合使用的情况。

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