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首页> 外文期刊>Journal of Ginseng Research >Non-clinical pharmacokinetic behavior of ginsenosides
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Non-clinical pharmacokinetic behavior of ginsenosides

机译：人参皂甙的非临床药代动力学行为

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摘要

Ginsenosides, the major active ingredients of ginseng and other plants of the genus Panax , have been used as natural medicines in the East for a long time; in addition, their popularity in the West has increased owing to their various beneficial pharmacological effects. There is therefore a wealth of literature regarding the pharmacological effects of ginsenosides. In contrast, there are few comprehensive studies that investigate their pharmacokinetic behaviors. This is because ginseng contains the complicated mixture of herbal materials as well as thousands of constituents with complex chemical properties, and ginsenosides undergo multiple biotransformation processes after administration. This is a significant issue as pharmacokinetic studies provide crucial data regarding the efficacy and safety of compounds. Moreover, there have been many difficulties in the development of the optimal dosage regimens of ginsenosides and the evaluation of their interactions with other drugs. Therefore, this review details the pharmacokinetic properties and profiles of ginsenosides determined in various animal models administered through different routes of administration. Such information is valuable for designing specialized delivery systems and determining optimal dosing strategies for ginsenosides.
机译：人参和人参及其他人参植物的主要活性成分人参皂甙在东方地区已长期用作天然药物。此外，由于其各种有益的药理作用，它们在西方的流行也有所增加。因此，关于人参皂苷药理作用的文献很多。相反，很少有研究其药代动力学行为的综合研究。这是因为人参包含复杂的草药材料混合物以及数千种具有复杂化学特性的成分，人参皂甙在给药后会经历多次生物转化过程。这是一个重大问题，因为药代动力学研究提供了有关化合物功效和安全性的关键数据。此外，在开发人参皂苷最佳剂量方案以及评估它们与其他药物的相互作用方面存在许多困难。因此，本综述详细介绍了在通过不同给药途径给药的各种动物模型中确定的人参皂苷的药代动力学特性和特征。此类信息对于设计专业的输送系统和确定人参皂甙的最佳给药策略非常有用。

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