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首页> 外文期刊>Journal of Ginseng Research >Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments
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Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments

机译：人参皂甙Rb1改善顺铂诱导的学习和记忆障碍

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Background Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root, exhibits neuroprotective functions in many neurological diseases. This study was intended to investigate whether Rb1 can attenuate cisplatin-induced memory impairments and explore the potential mechanisms. Methods Cisplatin was injected intraperitoneally with a dose of 5?mg/kg/wk, and Rb1 was administered in drinking water at the dose of 2?mg/kg/d to rats for 5 consecutive wk. The novel objects recognition task and Morris water maze were used to detect the memory of rats. Nissl staining was used to examine the neuron numbers in the hippocampus. The activities of superoxide dismutase, glutathione peroxidase, cholineacetyltransferase, acetylcholinesterase, and the levels of malondialdehyde, reactive oxygen species, acetylcholine, tumor necrosis factor-α, interleukin-1β, and interleukin-10 were measured by ELISA to assay the oxidative stress, cholinergic function, and neuroinflammation in the hippocampus. Results Rb1 administration effectively ameliorates the memory impairments caused by cisplatin in both novel objects recognition task and Morris water maze task. Rb1 also attenuates the neuronal loss induced by cisplatin in the different regions (CA1, CA3, and dentate gyrus) of the hippocampus. Meanwhile, Rb1 is able to rescue the cholinergic neuron function, inhibit the oxidative stress and neuroinflammation in cisplatin-induced rat brain. Conclusion Rb1 rescues the cisplatin-induced memory impairment via restoring the neuronal loss by reducing oxidative stress and neuroinflammation and recovering the cholinergic neuron functions.
机译：背景人参皂苷Rb1（Rb1）是人参根提取物的主要成分，在许多神经系统疾病中均具有神经保护功能。这项研究旨在调查Rb1是否可以减轻顺铂诱导的记忆障碍，并探讨潜在的机制。方法腹腔注射顺铂5？mg / kg / wk，大鼠连续5周连续以2？mg / kg / d的剂量在饮用水中给予Rb1。通过新颖的物体识别任务和莫里斯水迷宫来检测大鼠的记忆。 Nissl染色用于检查海马中的神经元数量。用ELISA法测定超氧化物歧化酶，谷胱甘肽过氧化物酶，胆碱乙酰基转移酶，乙酰胆碱酯酶的活性以及丙二醛，活性氧，乙酰胆碱，肿瘤坏死因子-α，白介素-1β和白介素10的水平，以测定氧化应激，胆碱能功能和海马神经炎症。结果Rb1给药可有效改善顺铂在新物体识别任务和莫里斯水迷宫任务中的记忆障碍。 Rb1还减轻了顺铂在海马不同区域（CA1，CA3和齿状回）引起的神经元丢失。同时，Rb1能够挽救胆碱能神经元功能，抑制顺铂诱导的大鼠脑中的氧化应激和神经炎症。结论Rb1可通过减轻氧化应激和神经炎症并恢复胆碱能神经元功能来恢复神经元丢失，从而挽救顺铂引起的记忆障碍。

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