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首页> 外文期刊>Journal of Functional Biomaterials >Three-Dimensional Bone Substitutes for Oral and Maxillofacial Surgery: Biological and Structural Characterization
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Three-Dimensional Bone Substitutes for Oral and Maxillofacial Surgery: Biological and Structural Characterization

机译：口腔颌面外科手术的三维骨替代物：生物学和结构表征

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Background: Bone substitutes, either from human (autografts and allografts) or animal (xenografts) sources, suffer from inherent drawbacks including limited availability or potential infectivity to name a few. In the last decade, synthetic biomaterials have emerged as a valid alternative for biomedical applications in the field of orthopedic and maxillofacial surgery. In particular, phosphate-based bone substitution materials have exhibited a high biocompatibility due to their chemical similitude with natural hydroxyapatite. Besides the nature of the biomaterial, its porous and interconnected architecture is essential for a correct osseointegration. This performance could be predicted with an extensive characterization of the biomaterial in vitro. Methods: In this study, we compared the biological, chemical, and structural features of four different commercially available bone substitutes derived from an animal or a synthetic source. To this end, μ-CT and SEM were used to describe the biomaterials structure. Both FTIR and EDS analyses were carried out to provide a chemical characterization. The results obtained by these techniques were correlated with cell adhesion and proliferation of the osteosarcoma MG-63 human cell line cultured in vitro. Results: The findings reported in this paper indicate a significant influence of both the nature and the structure of the biomaterials in cell adhesion and proliferation, which ultimately could affect the clinical performance of the biomaterials. Conclusions: The four commercially available bone substitutes investigated in this work significantly differed in terms of structural features, which ultimately influenced in vitro cell proliferation and may so affect the clinical performance of the biomaterials.
机译：背景：来自人类（自体移植和同种异体移植）或动物（异种移植）来源的骨替代品都存在固有的缺陷，包括有限的可用性或潜在的传染性。在过去的十年中，合成生物材料已成为骨科和颌面外科领域中生物医学应用的有效替代品。特别地，基于磷酸盐的骨替代材料由于其与天然羟基磷灰石的化学相似性而显示出高的生物相容性。除了生物材料的性质外，其多孔且相互连接的体系结构对于正确的骨整合至关重要。可以通过体外生物材料的广泛表征来预测这种性能。方法：在这项研究中，我们比较了从动物或合成来源衍生的四种不同的市售骨替代物的生物学，化学和结构特征。为此，使用μ-CT和SEM来描述生物材料的结构。进行了FTIR和EDS分析以提供化学特征。通过这些技术获得的结果与体外培养的骨肉瘤MG-63人细胞系的细胞粘附和增殖相关。结果：本文报道的发现表明，生物材料的性质和结构对细胞粘附和增殖均具有重大影响，最终可能会影响生物材料的临床性能。结论：在这项工作中研究的四种市售骨替代物在结构特征方面存在显着差异，这最终影响了体外细胞增殖，因此可能会影响生物材料的临床性能。

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