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首页> 外文期刊>Journal of Gastrointestinal Oncology >Local excision for patients with stage I anal canal squamous cell carcinoma can be curative
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Local excision for patients with stage I anal canal squamous cell carcinoma can be curative

机译：I期肛管鳞状细胞癌的局部切除可以治愈

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Background: Definitive concurrent chemoradiation is the current standard of care for all stage I anal canal squamous cell carcinoma. Local excision as primary treatment for selected stage I lesions has been reported in the literature but is not currently recommended by major guidelines. We herein compared the oncologic outcomes of patients with stage I anal canal squamous cell carcinoma treated with local excision alone versus chemoradiation to determine if there are any significant differences in outcomes including disease free survival, overall survival (OS) and local failure rate. Methods: A retrospective review of all patients treated for stage I anal canal squamous cell carcinoma between 1990 and 2016 was conducted. Data collected included baseline demographics, staging studies, pathology, treatment received, relapse pattern and survival. Results: A total of 57 patients were treated for stage I anal canal squamous cell carcinoma between 1990 and 2016; 13 were treated with local excision alone and 44 were treated with chemoradiation therapy. Baseline characteristics in both cohorts of patients were comparable. Median follow-up duration of the local excision and the chemoradiation cohorts were 106 and 70 months, respectively. Of the 13 patients in local excision cohort, two patients had disease recurrence, at 21 and 97 months from the diagnosis. Both patients were long term survivors with salvage treatment. In chemoradiation cohort, 1 out of 44 patients had a local recurrence at 1 year who underwent curative resection. Five-year progression free survival (PFS) of subjects in local excision cohort and chemoradiation cohort were 91% and 83%, respectively (P=0.57). Conclusions: Local excision as primary treatment may be safe and effective for a selected group of stage I anal canal squamous cell carcinoma patients.
机译：背景：明确的同时放化疗是目前所有I期肛管鳞状细胞癌的护理标准。文献报道了局部切除术作为选择的I期病变的主要治疗方法，但目前尚未被主要指南推荐。我们在本文中比较了仅通过局部切除与化学放疗治疗的I期肛管鳞状细胞癌患者的肿瘤学结局，以确定结局是否存在显着差异，包括无病生存期，总生存期（OS）和局部失败率。方法：回顾性分析1990年至2016年间所有接受I期肛管鳞状细胞癌治疗的患者。收集的数据包括基线人口统计学，分期研究，病理学，所接受的治疗，复发模式和生存率。结果：1990年至2016年间，共有57例患者接受了I期肛管鳞状细胞癌的治疗; 13例仅接受局部切除治疗，44例接受化学放射治疗。两组患者的基线特征均具有可比性。局部切除术和化学放疗队列的中位随访时间分别为106个月和70个月。在局部切除队列的13例患者中，有2例在诊断后21和97个月复发。两名患者均为接受挽救治疗的长期幸存者。在化学放疗队列中，44例患者中有1例在1年时局部复发，接受了根治性切除。局部切除队列和化学放疗队列的受试者的五年无进展生存期（PFS）分别为91％和83％（P = 0.57）。结论：局部切除作为一级治疗可能对选择的一组I期肛管鳞状细胞癌患者是安全有效的。

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