High-Risk Leukemia: Past, Present, and Future Role of NK Cells

Melissa Mavers; Alice Bertaina

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High-Risk Leukemia: Past, Present, and Future Role of NK Cells

机译：高危白血病：NK细胞的过去，现在和将来的作用

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Natural killer (NK) cells are a population of cytotoxic innate lymphocytes that evolved prior to their adaptive counterparts and constitute one of the first lines of defense against infected/mutated cells. Several studies have shown that in patients with acute leukemia given haploidentical hematopoietic stem cell transplantation, donor-derived NK cells play a key role in the eradication of cancer cells. The antileukemic effect is mostly related to the presence of “alloreactive” NK cells, that is, mature KIR

机译：天然杀伤（NK）细胞是细胞毒性先天淋巴细胞的群体，先于它们的适应性对应细胞进化而成，并且构成了抵御感染/突变细胞的第一道防线之一。多项研究表明，在接受单倍体造血干细胞移植的急性白血病患者中，供体来源的NK细胞在根除癌细胞中起关键作用。抗白血病作用主要与“同种反应性” NK细胞的存在有关，即成熟的KIR

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《Journal of immunology research.》 |2018年第2期|共页
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Melissa Mavers; Alice Bertaina;
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中图分类免疫性疾病;
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1. High-Risk Leukemia: Past, Present, and Future Role of NK Cells [J] . Melissa Mavers, Alice Bertaina Clinical & developmental immunology. . 2018,第1期

机译：高风险的白血病：NK细胞的过去，现在和未来的作用
2. High-Risk Leukemia: Past, Present, and Future Role of NK Cells [J] . Melissa Mavers, Alice Bertaina Journal of immunology research. . 2018,第2期

机译：高危白血病：NK细胞的过去，现在和将来的作用
3. High-risk acute lymphoblastic leukemia cells with bcr-abl and INK4A/ARF mutations retain susceptibility to alloreactive T cells. [J] . Young FM, Campbell A, Emo KL, Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation . 2008,第6期

机译：具有bcr-abl和INK4A / ARF突变的高危急性淋巴细胞性白血病细胞对同种反应性T细胞保持敏感性。
4. High-risk cutaneous squamous cell carcinoma of the head and neck: The role of adjuvant radiotherapy. [C] . Veness M. International Congress of Dermatology . 2009

机译：头部和颈部高风险皮肤鳞状细胞癌：佐剂放射疗法的作用。
5. Evaluating the role of dendritic cells in host immune response during human T cell leukemia virus type 1 (HTLV-1) infection using a transgenic mouse model system [D] . Rahman, Saifur 2010

机译：使用转基因小鼠模型系统评估树突状细胞在人T细胞白血病病毒1型（HTLV-1）感染期间宿主免疫反应中的作用
6. High-Risk Leukemia: Past Present and Future Role of NK Cells [O] . Melissa Mavers, Alice Bertaina 2018

机译：高危白血病：NK细胞的过去现在和将来的作用
7. Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells [O] . Locatelli F, Pende D, Mingari MC, 2013

机译：单倍型造血干细胞移植在成功治疗高危白血病中的细胞和分子基础：同种反应性NK细胞的作用

High-Risk Leukemia: Past, Present, and Future Role of NK Cells

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