...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of immunology research. >Glutamine Randomized Studies in Early Life: The Unsolved Riddle of Experimental and Clinical Studies
【24h】

Glutamine Randomized Studies in Early Life: The Unsolved Riddle of Experimental and Clinical Studies

机译：早期谷氨酰胺随机研究：实验和临床研究的未解之谜

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Glutamine may have benefits during immaturity or critical illness in early life but its effects on outcome end hardpoints are controversial. Our aim was to review randomized studies on glutamine supplementation in pups, infants, and children examining whether glutamine affects outcome. Experimental work has proposed various mechanisms of glutamine action but none of the randomized studies in early life showed any effect on mortality and only a few showed some effect on inflammatory response, organ function, and a trend for infection control. Although apparently safe in animal models (pups), premature infants, and critically ill children, glutamine supplementation does not reduce mortality or late onset sepsis, and its routine use cannot be recommended in these sensitive populations. Large prospectively stratified trials are needed to better define the crucial interrelations of “glutamine-heat shock proteins-stress response” in critical illness and to identify the specific subgroups of premature neonates and critically ill infants or children who may have a greater need for glutamine and who may eventually benefit from its supplementation. The methodological problems noted in the reviewed randomized experimental and clinical trials should be seriously considered in any future well-designed large blinded randomized controlled trial involving glutamine supplementation in critical illness.
机译：谷氨酰胺在未成熟或生命早期危重症中可能有益处，但对结局终点的影响尚存争议。我们的目的是审查在幼犬，婴儿和儿童中补充谷氨酰胺的随机研究，以检查谷氨酰胺是否会影响预后。实验工作提出了谷氨酰胺作用的各种机制，但早期的随机研究均未显示对死亡率有任何影响，只有少数对炎症反应，器官功能和感染控制趋势有影响。尽管谷氨酰胺补充剂在动物模型（幼崽），早产儿和重症儿童中显然是安全的，但补充谷氨酰胺并不能降低死亡率或迟发性败血症，因此不建议在这些敏感人群中常规使用谷氨酰胺。需要进行大型的前瞻性分层试验，以更好地定义危重病中“谷氨酰胺-热休克蛋白-应激反应”的关键相互关系，并确定早产新生儿和危重婴儿或儿童的特定亚组，他们可能更需要谷氨酰胺和谁最终可能会从其补充中受益。在任何未来设计良好，涉及重大疾病的补充谷氨酰胺的大型盲实验中，都应认真考虑所审查的随机实验和临床试验中指出的方法学问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号