...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Hainan Medical University >Relationship between serum inflammatory response cytokines and the change of plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis
【24h】

Relationship between serum inflammatory response cytokines and the change of plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis

机译：H型高血压合并颈动脉粥样硬化患者血清炎症反应细胞因子与斑块性质变化的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To study the relationship between serum inflammatory response cytokines andthe change of plaque properties in patients with H-type hypertension complicated by carotidatherosclerosis. Methods: Patients who were diagnosed with H-type hypertension complicatedby carotid atherosclerosis in Yulin Hospital of Traditional Chinese Medicine between May2014 and December 2016 were selected as group A, patients with H-type hypertensioncomplicated by carotid atherosclerosis and normal Hcy levels were selected as group B,patients with carotid atherosclerosis and normal blood pressure levels and Hcy levels wereselected as group C, and healthy volunteers during the same period were selected as controlgroup. Serum levels of inflammatory response cytokines and plaque property-related cytokineswere detected. Results: Serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9and Caspase-3 levels of group A, group B and group C were significantly higher than those ofgroup D, serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3levels of group A and group B were significantly higher than those of group C, and serumHcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of groupA were significantly higher than those of group B; serum Hcy, sICAM-1, MCP-1, YKL-40,IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A with vulnerable plaques weresignificantly higher than those of patients with stable plaques. Serum Hcy, sICAM-1, MCP-1,YKL-40 and IL-6 levels of group A were positively correlated with PTX3, FGF23, MMP9 andCaspase-3 levels. Conclusion: Serum inflammatory response cytokine secretion increases inpatients with H-type hypertension complicated by carotid atherosclerosis, and it can result inthe change in plaque properties and the decrease in stability.
机译：目的：探讨H型高血压合并颈动脉粥样硬化患者血清炎症反应细胞因子与斑块性质变化的关系。方法：选择2014年5月至2016年12月在榆林市中医院诊断为H型高血压并发颈动脉粥样硬化的患者作为A组，将H型高血压并发颈动脉粥样硬化且Hcy水平正常的患者作为B组。选择颈动脉粥样硬化，血压，Hcy正常的患者为C组，同期健康志愿者为对照组。检测血清的炎症反应细胞因子水平和与斑块特性相关的细胞因子。结果：A，B，C组血清Hcy，sICAM-1，MCP-1，YKL-40，IL-6，PTX3，FGF23，MMP9和Caspase-3水平明显高于D组。 A组和B组的sICAM-1，MCP-1，YKL-40，IL-6，PTX3，FGF23，MMP9和Caspase-3水平显着高于C组，血清Hcy，sICAM-1，MCP-1 A组的YKL-40，IL-6，PTX3，FGF23，MMP9和Caspase-3水平显着高于B组。 A组易损斑块的血清Hcy，sICAM-1，MCP-1，YKL-40，IL-6，PTX3，FGF23，MMP9和Caspase-3水平显着高于稳定斑块的患者。 A组血清Hcy，sICAM-1，MCP-1，YKL-40和IL-6水平与PTX3，FGF23，MMP9和Caspase-3水平呈正相关。结论：H型高血压合并颈动脉粥样硬化患者血清炎症反应细胞因子的分泌增加，可导致斑块性质改变和稳定性降低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号