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首页> 外文期刊>Journal of Hainan Medical University >Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure
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Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure

机译：氨溴索纤维支气管镜支气管肺泡灌洗对重症肺炎并发呼吸衰竭患者SIRS和靶器官损害的影响

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Objective: To study the effect of fiberoptic bronchoscopic bronchoalveolar lavage withambroxol on the systemic inflammatory response syndrome (SIRS) and target organ damagein patients with severe pneumonia complicated by respiratory failure. Methods: A total of68 patients with severe pneumonia complicated by respiratory failure who received inpatienttreatment in our hospital between July 2013 and December 2016 were collected and thendivided into the control group (n=35) who received conventional therapy and the observationgroup (n=33) who received fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol +conventional therapy after the therapies were reviewed. The systemic inflammatory responseas well as cardiac and liver function before and after treatment were compared between twogroups of patients. Results: Before treatment, differences in serum levels of inflammatoryfactors, myocardial enzyme spectrum and liver function indexes were not statisticallysignificant between the two groups of patients. After treatment, serum inflammatory factorsIL-6, IL-8, TNF-毩 and CRP levels in observation group were lower than those in controlgroup; serum myocardial enzyme spectrum LDH, 毩-HBDH, CKMB and cTnI levels werelower than those in control group; serum liver function index Alb content was higher than thatin control group while ALP, TBA, ALT and AST contents were lower than those in controlgroup. Conclusion: Fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol caneffectively reduce the degree of SIRS, and also reduce the cardiac and liver function injury inpatients with severe pneumonia complicated by respiratory failure.
机译：目的：研究氨溴索对纤维支气管镜支气管肺泡灌洗对严重肺炎并发呼吸衰竭患者的全身炎症反应综合征（SIRS）和靶器官损害的影响。方法：收集2013年7月至2016年12月在我院住院治疗的68例重症肺炎并发呼吸衰竭的患者，分为常规治疗的对照组（n = 35）和观察组（n = 33）。谁接受了纤维支气管镜支气管肺泡灌洗与氨溴索+常规疗法治疗后进行了审查。比较两组患者治疗前后的全身炎症反应以及心脏和肝功能。结果：治疗前，两组患者的血清炎症因子水平，心肌酶谱和肝功能指标差异均无统计学意义。治疗后观察组血清炎性因子IL-6，IL-8，TNF-α和CRP水平低于对照组。血清心肌酶谱LDH，毩-HBDH，CKMB和cTnI水平低于对照组。血清肝功能指标Alb含量高于对照组，而ALP，TBA，ALT和AST含量低于对照组。结论：氨溴索在纤维支气管镜下支气管肺泡灌洗可有效降低SIRS程度，并减轻重症肺炎并发呼吸衰竭患者的心肝功能损害。

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