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首页> 外文期刊>Journal of Hainan Medical University >Fetal middle cerebral artery blood flow characteristics of gestational hypertension combined with fetal distress in uterus as well as their correlation with hypoxia
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Fetal middle cerebral artery blood flow characteristics of gestational hypertension combined with fetal distress in uterus as well as their correlation with hypoxia

机译：妊娠高血压综合征合并胎儿宫内窘迫的胎儿中脑动脉血流特征及其与缺氧的关系

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Objective: To study the fetal middle cerebral artery blood flow characteristics of gestational hypertension combined with fetal distress in uterus as well as their correlation with hypoxia. Methods: Puerperae with hypertensive disorders in pregnancy and fetal distress in uterus, puerperae with hypertensive disorders in pregnancy alone and healthy puerperae who gave birth in our hospital between January 2013 and January 2016 were included in group A, group B and group C of the study respectively. At 34-36 weeks of pregnancy, color Doppler ultrasonography was conducted to determine fetal middle cerebral artery blood flow parameters; after childbirth, umbilical arterial blood was collected to determine blood gas analysis parameters, and the placenta tissue was collected to determine oxidative stress and mitochondria damage indexes. Results: Fetal middle cerebral artery S/D, PI and RI of group A were significantly higher than those of group B and group C while umbilical artery pH value and PaO2 as well as HCO3 - and BE content were significantly lower than those of group B and group C; fetal middle cerebral artery S/D, PI and RI as well as umbilical artery pH value, PaO2, HCO3 - and BE content of group B were not significantly different from those of group C; Nrf2, ARE, NQO1, VitC, SVCT1, SVCT2, ATP, PGC-1α, PGC-1毬, NRF1 and NRF2 content in placenta tissue of group A were significantly lower than those of group B and group C while ROS content was significantly higher than those of group B and group C; Nrf2, ARE, NQO1, VitC, SVCT1, SVCT2, ATP, PGC-1α, PGC-1毬, NRF1 and NRF2 content in placenta tissue of group B were significantly lower than those of group C while ROS content was significantly higher than that of group C. Fetal middle cerebral artery S/D, PI and RI were negatively correlated with umbilical artery pH value, PaO2, HCO3 - and BE content as well as Nrf2, ARE, NQO1, VitC, SVCT1, SVCT2, ATP, PGC-1α, PGC-1毬, NRF1 and NRF2 content, and were positively correlated with ROS content. Conclusions: Gestational hypertension combined with fetal distress in uterus can lead to increased fetal middle cerebral artery blood flow resistance and decreased blood perfusion, and the changes of middle cerebral artery blood flow characteristics can assess the degree of hypoxia and oxidative stress damage.
机译：目的：研究妊娠高血压合并胎儿宫内窘迫的胎儿中脑动脉血流特征及其与缺氧的关系。方法：将2013年1月至2016年1月在我院分娩的妊娠高血压合并子宫窘迫的产妇，子宫单纯妊娠合并高血压的产妇和健康产妇纳入研究的A组，B组和C组。分别。在妊娠34-36周时，进行彩色多普勒超声检查以确定胎儿大脑中动脉的血流参数。分娩后，收集脐动脉血以确定血气分析参数，并收集胎盘组织以确定氧化应激和线粒体损伤指数。结果：A组胎儿大脑中动脉S / D，PI和RI明显高于B组和C组，脐动脉pH值，PaO2，HCO3和BE含量明显低于B组C组; B组胎儿的大脑中动脉S / D，PI和RI以及脐动脉pH值，PaO2，HCO3和BE含量与C组无明显差异。 A组胎盘组织中Nrf2，ARE，NQO1，VitC，SVCT1，SVCT2，ATP，PGC-1α，PGC-1毬，NRF1和NRF2的含量均显着低于B组和C组，而ROS含量显着较高高于B组和C组; B组胎盘组织中Nrf2，ARE，NQO1，VitC，SVCT1，SVCT2，ATP，PGC-1α，PGC-1毬，NRF1和NRF2的含量显着低于C组，而ROS的含量显着高于C组。胎中脑动脉S / D，PI和RI与脐动脉pH值，PaO2，HCO3-和BE含量以及Nrf2，ARE，NQO1，VitC，SVCT1，SVCT2，ATP，PGC-1α呈负相关，PGC-1毬，NRF1和NRF2的含量，与ROS含量呈正相关。结论：妊娠高血压合并胎儿宫内窘迫可导致胎儿中脑动脉血流阻力增加和血液灌注减少，中脑动脉血流特征的变化可评估缺氧程度和氧化应激损伤程度。

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