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首页> 外文期刊>Journal of Hainan Medical University >Effect of glucocorticoid inhalation combined with oral montelukast on airway function and serum inflammatory cytokines in patients with bronchial asthma
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Effect of glucocorticoid inhalation combined with oral montelukast on airway function and serum inflammatory cytokines in patients with bronchial asthma

机译：糖皮质激素吸入联合口服孟鲁司特对支气管哮喘患者气道功能和血清炎性细胞因子的影响

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Objective: To study the effect of glucocorticoid inhalation combined with oral montelukaston airway function and serum inflammatory cytokines in patients with bronchial asthma.Methods: 138 patients diagnosed with bronchial asthma in our hospital between August2014 and February 2016 were selected and randomly divided into two groups (n=69),observation group received oral montelukast combined with symbicort inhalation treatment,and control group received symbicort inhalation treatment. 3 months and 6 months aftertreatment, spirometer was used to measure the airway function parameters, and enzymelinkedimmunosorbent assay kits were used to determine Th1/Th2, Treg/Th17 and Th9/cTfhcytokine content. Results: 3 months and 6 months after treatment, 1 second (FEV1)/forcedvital capacity (FVC), tidal expiratory flow at 25%, 50% and 75% of tidal volume (TEF25%,TEF50% and TEF75%) of observation group were significantly higher than those of controlgroup (P0.05); serum interleukin-2 (IL-2), interferon-γ (IFN-γ), tumor necrosis factor(TNF-α), IL-10 and transforming growth factor (TGF-β) levels of observation group weresignificantly higher than those of control group (P0.05) while IL-4, IL-6, IL-17, IL-22, IL-9and IL-21 levels were significantly lower than those of control group (P0.05). Conclusions:Montelukast combined with conventional inhalation treatment of bronchial asthma can moreeffectively improve the airway function and inhibit the airway inflammatory response mediatedby Th1/Th2, Treg/Th17 and Th9/cTfh imbalance.
机译：目的：研究糖皮质激素吸入联合口服孟鲁司通通气功能和血清炎性细胞因子在支气管哮喘中的作用。方法：选择2014年8月至2016年2月在我院诊断为支气管哮喘的138例患者，随机分为两组（ n = 69），观察组接受孟鲁司特口服联合西必克吸入治疗，对照组接受西必克吸入治疗。治疗后3个月和6个月，使用肺活量计测量呼吸道功能参数，并使用酶联免疫吸附测定试剂盒测定Th1 / Th2，Treg / Th17和Th9 / cTfh细胞因子含量。结果：治疗后3个月和6个月，观察组的潮气量分别为TEF25％，TEF50％和TEF75％的25％，50％和75％，分别为1秒（FEV1）/强制肺活量（FVC），潮气量。明显高于对照组（P <0.05）;观察组血清白细胞介素2（IL-2），干扰素-γ（IFN-γ），肿瘤坏死因子（TNF-α），IL-10和转化生长因子（TGF-β）水平明显高于对照组。组（P <0.05），而IL-4，IL-6，IL-17，IL-22，IL-9和IL-21水平明显低于对照组（P <0.05）。结论：孟鲁司特联合常规吸入治疗支气管哮喘可更有效地改善气道功能，并抑制Th1 / Th2，Treg / Th17和Th9 / cTfh失衡介导的气道炎症反应。

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