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首页> 外文期刊>Journal of health, population, and nutrition >Do fatty acids affect fetal programming?
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Do fatty acids affect fetal programming?

机译：脂肪酸会影响胎儿编程吗？

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Background In this study discussed the primary and regulatory roles of fatty acids, and investigated the affects of fatty acids on metabolic programming. Methods Review of the literature was carried out on three electronic databases to assess the roles of fatty acids in metabolic programming. All abstracts and full-text articles were examined, and the most relevant articles were selected for screening and inclusion in this review. Results The mother’s nutritional environment during fetal period has important effects on long term health. Fatty acids play a primary role in growth and development. Alterations in fatty acid intake in the fetal period may increase the risk of obesity and metabolic disorders in later life. Maternal fatty acid intakes during pregnancy and lactation are passed to the fetus and the newborn via the placenta and breast milk, respectively. Imbalances in fatty acid intake during the fetal period change the fatty acid composition of membrane phospholipids, which can cause structural and functional problems in cells. Additionally, the metabolic and neuroendocrine environments of the fetus and the newborn play key roles in the regulation of energy balance. Conclusions Imbalances in fatty acid intake during pregnancy and lactation may result in permanent changes in appetite control, neuroendocrine function and energy metabolism in the fetus, leading to metabolic programming. Further studies are needed to determine the role of fatty acid intake in metabolic programming.
机译：背景技术在本研究中，讨论了脂肪酸的主要作用和调节作用，并研究了脂肪酸对代谢程序设计的影响。方法在三个电子数据库上进行文献综述，以评估脂肪酸在代谢程序设计中的作用。检查了所有摘要和全文文章，并选择了最相关的文章进行筛选和纳入本次审查。结果胎儿时期母亲的营养环境对长期健康具有重要影响。脂肪酸在生长发育中起主要作用。胎儿期脂肪酸摄入的变化可能会增加以后生活中肥胖和代谢紊乱的风险。孕妇在怀孕和哺乳期间摄入的脂肪酸分别通过胎盘和母乳传递给胎儿和新生儿。胎儿时期脂肪酸摄入的不平衡会改变膜磷脂的脂肪酸组成，从而可能导致细胞的结构和功能问题。另外，胎儿和新生儿的代谢和神经内分泌环境在调节能量平衡中起关键作用。结论妊娠和哺乳期间脂肪酸摄入的失衡可能导致胎儿食欲控制，神经内分泌功能和能量代谢的永久性改变，从而导致代谢程序设计。需要进一步的研究以确定脂肪酸摄入在代谢程序中的作用。

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