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首页> 外文期刊>Journal of Hainan Medical University >Effect of urokinase in combined with minimally invasive intracranial hematoma evacuation on serum ferritin, serum P substance, inflammatory factors and vascular endothelial function in patients with hypertensive intracerebral hemorrhage
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Effect of urokinase in combined with minimally invasive intracranial hematoma evacuation on serum ferritin, serum P substance, inflammatory factors and vascular endothelial function in patients with hypertensive intracerebral hemorrhage

机译：尿激酶联合微创颅内血肿清除术对高血压脑出血患者血清铁蛋白，血清P物质，炎性因子和血管内皮功能的影响

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Objective: To investigate the effects of minimally invasive evacuation of intracranial hematomaon serum SP, SF, vascular endothelial function and inflammatory factors of patients withhypertensive intracerebral hemorrhage. Methods: According to random data table method,a total of 120 patients with hypertensive cerebral hemorrhage from September 2016 to May2017 were divided into observation group and the control group, 60 cases in each group. Thecontrol group was treated with conventional treatment; on the basis of conventional treatment,the observation group underwent minimally invasive evacuation of intracranial hematoma.The levels of serum SF, SP, vascular endothelial function and inflammatory factors changeswere compared between the two groups before and after the treatment. Results: Beforetreatment, the levels of serum SP, SF, NO, ET-1, hs-CRP, IL-6, TNF-α in the two groups werenot statistically significant. The levels of hs-CRP, IL-6, TNF-α, SF, ET-1 after treatment intwo groups were significantly lower than those in the same group before treatment, and theobservation group levels were significantly lower than those in the control group; the levelsof SP, NO in the two groups after treatment were significantly higher than before treatment,and the observation group was higher than that the control group with significant difference.Conclusion: The minimally invasive intracranial hematoma evacuation for patients with HICHcan effectively improve the levels of SP, SF, inflammatory factors and vascular endothelialfunction, which is helpful to relieve cerebral edema and lower intracranial pressure, andimprove the quality of treatment.
机译：目的：探讨微创排空颅内血肿对高血压脑出血患者血清SP，SF，血管内皮功能和炎性因子的影响。方法：采用随机数据表法，将2016年9月至2017年5月的120例高血压脑出血患者分为观察组和对照组，每组60例。对照组采用常规治疗。观察组在常规治疗的基础上进行颅内血肿的微创排空。比较两组治疗前后血清SF，SP，血管内皮功能和炎症因子的变化。结果：两组治疗前血清SP，SF，NO，ET-1，hs-CRP，IL-6，TNF-α水平无统计学意义。两组治疗后hs-CRP，IL-6，TNF-α，SF，ET-1水平明显低于治疗前同一组，观察组水平明显低于对照组。两组治疗后SP，NO水平明显高于治疗前，观察组高于对照组，差异有统计学意义。结论：HICH患者微创颅内血肿清除术可以有效提高患者的血铅水平。 SP，SF，炎性因子和血管内皮功能，有助于缓解脑水肿和降低颅内压，提高治疗质量。

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