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首页> 外文期刊>Journal of Hainan Medical University >Study on the mechanism of Yinzhihuang granules, Blue light irradiation combined with Bifid Triple Viable Capsules for neonatal jaundice treatment
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Study on the mechanism of Yinzhihuang granules, Blue light irradiation combined with Bifid Triple Viable Capsules for neonatal jaundice treatment

机译：银止黄冲剂，蓝光联合双歧双活胶囊治疗新生儿黄疸的机制研究

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Objective: To study the effect of perioperative fetal intrauterine hypoxia on maternal oxidativestress injury after cesarean section. Methods: 37 puerperae receiving cesarean section for fetalintrauterine hypoxia between May 2014 and December 2016 were selected as hypoxia groupand 40 puerperae receiving cesarean section during the same period and without complicationsduring pregnancy or fetal intrauterine hypoxia were selected as control group. Umbilicalarterial blood was collected after delivery of placenta for blood gas analysis, and the placentatissue and serum samples were collected to test the content of oxidative stress products andantioxidants. Results: Umbilical arterial blood gas analysis parameters pH value as well as PO2,HCO3- and BE content of hypoxia group were significantly lower than those of control group(P＜0.05); NADPH, reactive oxide species (ROS) and reactive nitrogen species (RNS) contentin placenta tissue of hypoxia group were significantly higher than those of control group (P＜0.05) while glutathione S-transferase (GST), glutathione peroxidase (GPx), superoxidedismutase (SOD), Trx, vitamin C (VitC), VitE and coenzyme Q10 (CoQ10) content weresignificantly lower than those of control group (P＜0.05); serum malondialdehyde (MDA) and8-iso-prostaglandin F2α (8-iso-PGF2α) content of hypoxia group were significantly higherthan those of control group (P＜0.05). Conclusions: Perioperative fetal intrauterine hypoxiacan lead to maternal oxidative stress injury after cesarean section and increase the generationof free radicals and the consumption of antioxidants.
机译：目的：探讨围手术期胎儿宫内缺氧对剖宫产术后母体氧化应激损伤的影响。方法：选择2014年5月至2016年12月接受剖宫产术治疗胎儿宫内缺氧的产妇为低氧组，选择同期无妊娠，胎儿或宫内缺氧并发剖宫产术的产妇40例为对照组。胎盘分娩后收集脐动脉血进行血气分析，并采集胎盘组织和血清样品以检测氧化应激产物和抗氧化剂的含量。结果：低氧组脐动脉血气分析参数pH值，PO2，HCO3-，BE含量均明显低于对照组（P ＜0.05）;低氧组胎盘组织中NADPH，活性氧化物和活性氮的含量均明显高于对照组（P ＜0.05），而谷胱甘肽S-转移酶（GST），谷胱甘肽过氧化物酶（GPx），超氧化物歧化酶（SOD），Trx，维生素C（VitC），VitE和辅酶Q10（CoQ10）含量均显着低于对照组（P ＜0.05）。缺氧组血清丙二醛（MDA）和8-异前列腺素F2α（8-异-PGF2α）含量明显高于对照组（P ＜0.05）。结论：围手术期胎儿宫内缺氧可导致剖宫产术后母体氧化应激损伤，并增加自由基的产生和抗氧化剂的消耗。

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