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首页> 外文期刊>Journal of Hainan Medical University >Effect of laparoscopic radical resection of colon cancer on immune function, stress response and gastrointestinal hormones in patients with colon cancer
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Effect of laparoscopic radical resection of colon cancer on immune function, stress response and gastrointestinal hormones in patients with colon cancer

机译：腹腔镜结肠癌根治术对结肠癌患者免疫功能，应激反应和胃肠激素的影响

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Objective: To investigate the effect of laparoscopic radical resection of colon cancer onimmune function, stress response and gastrointestinal hormones in patients with colon cancer.Method: 140 patients with colon cancer admitted to a hospital from January 2016 to November2017 were divided into control group and observation group according to the operation method,70 cases in each group. The control group was treated with open radical resection of coloncancer, while the observation group was treated with laparoscopic radical resection of coloncancer. The changes of immune function, stress response, visceral protein and gastrointestinalhormone were compared between the two groups before and after treatment. Results: Therewas no significant difference in immune function, stress response, visceral protein andgastrointestinal hormone between the two groups before operation (P0.05). The ratio ofTh1 cells was decreased, while the ratio of Th2, Th17 and Treg cells was increased in the twogroups (P0.05). The proportion of Th1 cells in the observation group was higher than thatin the control group,while the ratio of Th2, Th17 and Treg cells in the observation group waslower than that of the control group (P0.05). The levels of Cor, E and NE were increased inthe two groups (P0.05). And the levels of Cor, E and NE in the observation group were lowerthan those in the control group (P0.05). The levels of PA, TRF and RBP were decreased in thetwo groups (P0.05). And PA, TRF and RBP levels were higher in the observation group thanin the control group (P0.05). The GAS, MTL and GIP levels were lower in the two groups(P0.05). And the GAS, MTL and GIP levels in the observation group were higher than thosein the control group (P0.05). Conclusion: Laparoscopic radical mastectomy has little effecton the immune function of patients. It can alleviate the surgical stress response to a certainextent, which is beneficial to the recovery of gastrointestinal function and can be extended toclinical application.
机译：目的：探讨腹腔镜结肠癌根治术对结肠癌患者免疫功能，应激反应和胃肠激素的影响。方法：将2016年1月至2017年11月收治的140例结肠癌患者分为对照组和观察组。按手术方式分组，每组70例。对照组采用结肠癌的根治性根治性切除术，观察组采用腹腔镜结肠癌的根治性切除术。比较两组治疗前后免疫功能，应激反应，内脏蛋白和胃肠激素的变化。结果：两组患者术前的免疫功能，应激反应，内脏蛋白和胃肠激素无明显差异（P> 0.05）。两组Th1细胞比例降低，而Th2，Th17和Treg细胞比例升高（P <0.05）。观察组Th1细胞比例高于对照组，而观察组Th2，Th17和Treg细胞比例低于对照组（P <0.05）。两组的Cor，E和NE水平均升高（P <0.05）。观察组的Cor，E和NE水平低于对照组（P <0.05）。两组PA，TRF和RBP均降低（P <0.05）。观察组PA，TRF，RBP水平高于对照组（P <0.05）。两组的GAS，MTL和GIP水平均较低（P <0.05）。观察组GAS，MTL和GIP水平高于对照组（P <0.05）。结论：腹腔镜根治术对患者的免疫功能影响不大。它可以减轻一定程度上的手术压力反应，有利于胃肠功能的恢复，可以扩展到临床应用。

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