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首页> 外文期刊>Journal of Indian Academy of Oral Medicine and Radiology >Serum nicotine level among various tobacco users: A study
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Serum nicotine level among various tobacco users: A study

机译：各种烟草使用者的血清尼古丁水平：一项研究

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Introduction: The use of tobacco and its products has increased in the population over the past two decades, resulting in considerable systemic exposure to nicotine. Aims and Objectives: To estimate and compare the serum nicotine levels among smokers and gutkha chewers, along with the effect of nicotine replacement therapy on serum nicotine levels between them. Materials and Methods: Forty individuals were selected and divided into two groups with 20 individuals in each group. First group included individuals with a smoking habit, whereas the second group included individuals with the habit of chewing gutkha exclusively. Four blood samples were collected from all the participants in both the groups and subjected to serum nicotine estimation. Two blood samples were obtained (first sample after 30 min and the next sample after 60 min following smoking/chewing) on the first day, and the other two were obtained after 24 h of tobacco abstinence (after 24 h all the participants were asked to chew nicotine chewing gums each containing 2 mg of nicotine). Statistical Analysis Used: The particulars of age, frequency of habit (smoking and chewing gutkha), and serum nicotine levels before and after replacement therapy (nicotine chewing gum) were recorded and analyzed statistically by cross-tabulation for calculation of mean and frequency. Results: The serum concentration of nicotine in smokers at 30 min after smoking ranged 120-309 ng/ml and at 60 min ranged 29-77 ng/ml. In group 1, individuals' serum nicotine concentration after replacement therapy with nicotine chewing gum ranged 29-77 ng/ml at 30 min and 1-6 ng/ml at 60 min. Serum concentration of nicotine at 30 min after chewing gutkha ranged 86-200 ng/ml and at 60 min ranged 61-102 ng/ml. The serum nicotine concentration in group 2 individuals at 30 min following chewing nicotine gum ranged 24-55 ng/ml and at 60 min ranged 0-3 ng/ml. Conclusion: Serum nicotine concentration in chewers was less at 30 min and 60 min after chewing gutkha compared to smokers. Serum concentration after replacement therapy in chewers was slightly reduced after 30 min and considerably reduced after 60 min of chewing nicotine gum compared to smokers, indicating that nicotine levels were more in smokers than chewers and replacement therapy is effective in chewers than in smokers.
机译：简介：在过去的二十年中，烟草及其产品的使用在人口中增加了，导致大量系统性地暴露于尼古丁。目的和目的：评估和比较吸烟者和固特喀嚼烟者的血清尼古丁水平，以及尼古丁替代疗法对其之间血清尼古丁水平的影响。材料和方法：选择40个人，分为两组，每组20个人。第一组包括有吸烟习惯的人，而第二组包括仅咀嚼居特卡人的习惯。从两组的所有参与者中采集四份血液样本，并进行血清尼古丁估计。在第一天获得了两个血液样本（吸烟/咀嚼后30分钟后是第一个样本，吸烟/咀嚼后60分钟后是第二个样本），戒烟24小时后（另外24小时要求所有参与者咀嚼尼古丁口香糖，每个口香糖含2毫克尼古丁）。所使用的统计分析：记录并记录替代治疗前后（尼古丁口香糖）的年龄，习惯（吸烟和咀嚼古特卡）的频率以及血清尼古丁水平，并通过交叉列表进行统计分析以计算平均值和频率。结果：吸烟者在吸烟后30分钟的血清尼古丁浓度为120-309 ng / ml，在60分钟时为29-77 ng / ml。在第1组中，尼古丁口香糖替代治疗后，个体的血清尼古丁浓度在30分钟时为29-77 ng / ml，在60分钟时为1-6 ng / ml。咀嚼古特卡之后30分钟时，尼古丁的血清浓度为86-200 ng / ml，而在60分钟时为61-102 ng / ml。咀嚼尼古丁口香糖后30分钟，第2组个体的血清尼古丁浓度为24-55 ng / ml，60分钟时为0-3 ng / ml。结论：咀嚼苦瓜后30分钟和60分钟时，咀嚼者的血清尼古丁浓度低于吸烟者。与吸烟者相比，咀嚼剂替代治疗后的血清浓度在30分钟后略有降低，在咀嚼尼古丁胶后60分钟后血清浓度显着降低，这表明吸烟者的尼古丁水平高于咀嚼者，而替代疗法对咀嚼者的有效性高于吸烟者。

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