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首页> 外文期刊>Journal of Inborn Errors of Metabolism & Screening >Homocysteine and Psychiatric Disorders
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Homocysteine and Psychiatric Disorders

机译：同型半胱氨酸和精神病

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Psychiatric disorders are highly prevalent all over the world with a great impact on public health. Altered homocysteine metabolism is implicated in the pathogenesis of many of these disorders, as it can interfere in normal methylation of subcellular components, promote neuroexcitotoxicity, and induce oxidative stress and inflammation. There are cumulative data implicating these mechanisms in the development of autism, schizophrenia, depression, bipolar disorder, and Alzheimer disease. Altered homocysteine metabolism is multifactorial in its origin. On one hand, genetic factors act as predisposing factors through brain development and function, and on the other hand, environmental factors give the opportunity for nutritional interventions improving metabolic status and possibly also clinical parameters. This article provides a review on the association of 1-carbon metabolism and autism, schizophrenia, depression, bipolar disorder, and dementia and goes through studies on the role of different cofactors and metabolites involved in this pathway.
机译：精神疾病在世界范围内非常普遍，对公共卫生产生巨大影响。同型半胱氨酸代谢改变与许多此类疾病的发病机制有关，因为它可以干扰亚细胞成分的正常甲基化，促进神经兴奋毒性，并诱导氧化应激和炎症。有累积数据暗示这些机制与自闭症，精神分裂症，抑郁症，躁郁症和阿尔茨海默氏病的发展有关。同型半胱氨酸代谢改变的起因是多方面的。一方面，遗传因素是大脑发育和功能的诱发因素，另一方面，环境因素为营养干预措施提供了机会，可以改善代谢状况，也可能改善临床参数。本文对1-碳代谢与自闭症，精神分裂症，抑郁症，双相情感障碍和痴呆症的关系进行了综述，并研究了该途径中涉及的不同辅因子和代谢物的作用。

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