Activity of Epomediol in the Treatment of Hepatopathies: A Double-Blind Multi-Centre Study

L. Capurso; M. Kock; F. Ferrario; F. Del Sette; C. Gramolini; C. L. Castiglioni

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Activity of Epomediol in the Treatment of Hepatopathies: A Double-Blind Multi-Centre Study

机译：庚二醇在肝病治疗中的活性：双盲多中心研究

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A multi-centre study with epomediol discoids (200 mg three times daily for 30 days) versus placebo was carried out in 519 patients either with symptoms attributable to hepatopathy and/or alterations in the hepatic function. Epomediol was given to 257 patients chosen at random and the remaining 262 were given placebo. In cases of hepatopathy in which there was no severe damage to the hepatic parenchyma the symptoms of the disease were reduced and the laboratory parameters were improved on treatment with epomediol, whereas the activity of the drug was low in patients with chronic hepatopathy. This confirms that the clinical use of epomediol is most useful in cases of hepatopathy in which the change in hepatic function is still reversible.

机译：对519名患有归因于肝病和/或肝功能改变的症状的患者进行了一项关于环戊二烯类螺旋体（200毫克，每日3次，连续30天）的多中心研究。随机选择的257名患者接受了环氧丙二醇治疗，其余262名接受了安慰剂治疗。在肝实质未受到严重损害的肝病病例中，用庚二醇治疗可减轻疾病症状并改善实验室参数，而慢性肝病患者的药物活性较低。这证实了在临床仍可逆转肝功能变化的肝病病例中，环氧乙烷的临床应用最为有用。

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《Journal of International Medical Research》 |1987年第3期|共14页
作者
L. Capurso; M. Kock; F. Ferrario; F. Del Sette; C. Gramolini; C. L. Castiglioni;
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中图分类药学;
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Activity of Epomediol in the Treatment of Hepatopathies: A Double-Blind Multi-Centre Study

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