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首页> 外文期刊>Journal of International Medical Research >Prognosis and Expression of Lambda Light Chains in Solitary Extramedullary Plasmacytoma of the Head and Neck: Two Case Reports and a Literature Review
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Prognosis and Expression of Lambda Light Chains in Solitary Extramedullary Plasmacytoma of the Head and Neck: Two Case Reports and a Literature Review

机译：Lambda轻链在头颈部孤立性髓外浆细胞瘤的预后和表达：两个病例报告和文献综述。

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摘要

Two cases of extramedullary plasmacytoma (EMP) of the head and neck, an uncommon plasma cell neoplasm, were studied. Both patients had good outcomes and have been followed for 17 and 12 years without recurrence or systemic disease. In these two cases, the tumours measured were 4 cm and 0.3 cm, and both cases were positive for lambda light chain restriction on immunohistochemistry. Prognostic factors were considered, based on a review of EMP of the head and neck, including published reports and the authors' clinical experience. Of all plasma cell tumours, EMP has the best prognosis, especially when located in the head and neck region. Variation in the biological behaviour of EMP and the limited number of documented cases make it difficult to determine prognostic factors. Some series have found that age, tumour size, site of origin (extramedullary versus bone), grade, M-protein, light chains and radiotherapy dose all influence the outcome in EMP patients.
机译：研究了两个病例的头颈部髓外浆细胞瘤（EMP），一种罕见的浆细胞瘤。两名患者均具有良好的预后，并已随访17年和12年，无复发或全身性疾病。在这两种情况下，测得的肿瘤分别为4 cm和0.3 cm，并且两种情况在免疫组织化学上均为λ轻链限制阳性。根据对头颈部EMP的评估，包括已发表的报告和作者的临床经验，考虑了预后因素。在所有浆细胞肿瘤中，EMP的预后最好，尤其是位于头颈部区域时。 EMP生物学行为的变化和已记录病例的数量有限，使得难以确定预后因素。一些研究发现年龄，肿瘤大小，起源部位（髓外与骨骼），等级，M蛋白，轻链和放射治疗剂量均会影响EMP患者的预后。

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