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首页> 外文期刊>Journal of International Medical Research >The Role of T-Helper 17 (Th17) Cells in Patients with Medulloblastoma
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The Role of T-Helper 17 (Th17) Cells in Patients with Medulloblastoma

机译：T辅助细胞17（Th17）细胞在髓母细胞瘤患者中的作用

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As a new member of the CD4+ effector T-cell family, T-helper 17 (Th17) cells, have emerged as an important mediator in inflammatory and autoimmune diseases. Th17 cells preferentially produce interleukin (IL)-17A, IL-17F, IL-21, IL-22, and IL-26 in humans. Recent studies suggest a potential role for Th17 cells in tumour development. The current study was designed to investigate the possible involvement of Th17 cells in the brain tumour medulloblastoma. Compared with 17 healthy volunteers, 23 patients with medulloblastoma had a higher proportion of Th17 cells in their peripheral blood. Increased populations of Th17 cells were also present in medulloblastoma-infiltrating T-cells. Furthermore, the mRNA levels for Th17-related factors (IL-17, IL-23 and retinoid orphan nuclear receptor) in tumour tissues and the serum concentrations of IL-17 and IL-23 protein were significantly increased in patients with medulloblastoma. The results indicate that Th17 cells may contribute to medulloblastoma pathogenesis.
机译：作为CD4 +效应T细胞家族的新成员，T辅助17（Th17）细胞已成为炎症和自身免疫性疾病的重要介体。 Th17细胞优先在人体内产生白介素（IL）-17A，IL-17F，IL-21，IL-22和IL-26。最近的研究表明Th17细胞在肿瘤发展中的潜在作用。当前的研究旨在调查Th17细胞可能参与脑肿瘤髓母细胞瘤。与17名健康志愿者相比，23名髓母细胞瘤患者外周血Th17细胞比例更高。在髓母细胞瘤浸润的T细胞中也存在Th17细胞增加的群体。此外，髓母细胞瘤患者肿瘤组织中Th17相关因子（IL-17，IL-23和类维生素A孤儿核受体）的mRNA水平以及IL-17和IL-23蛋白的血清浓度显着升高。结果表明Th17细胞可能参与了髓母细胞瘤的发病机理。

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