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首页> 外文期刊>Journal of International Medical Research >Endocrine and Immune Effects of Dexamethasone in Unilateral Total Knee Replacement
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Endocrine and Immune Effects of Dexamethasone in Unilateral Total Knee Replacement

机译：地塞米松在单侧全膝关节置换术中的内分泌和免疫作用

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The effect of acute pre-surgery dexamethasone treatment on the inflammatory immune and endocrine responses to orthopaedic surgery was investigated. Whole blood samples were obtained before and 5 days after surgery for immune analysis, and serum was obtained before and 6 h, 3 days and 5 days after surgery for endocrine assessment. Dexamethasone did not affect the post-surgery granulocyte response, but inhibited the increase in monocyte count (an average increase of 38.5% was seen in the control group). Peak C-reactive protein concentration (3 days after surgery) was 51.4% lower in the dexamethasone group than in the control group. Dexamethasone had a major effect on cortisol concentrations and the cortisol:testosterone and cortisol: dehydroepiandrosterone ratios, but no effect on anabolic hormone concentrations. In conclusion, acute pre-surgery dexamethasone treatment may have beneficial effects in the post-surgery period, by limiting the extent of systemic inflammation and the cortisol response.
机译：研究了急性术前地塞米松治疗对骨科手术炎性免疫和内分泌反应的影响。在手术前和手术后5天采集全血样本进行免疫分析，在手术前和手术后6小时，3天和5天采集血清用于内分泌评估。地塞米松不影响手术后的粒细胞反应，但抑制了单核细胞计数的增加（对照组平均增加了38.5％）。地塞米松组的C反应蛋白峰值浓度（术后3天）比对照组低51.4％。地塞米松对皮质醇浓度和皮质醇：睾丸激素以及皮质醇：脱氢表雄甾酮比率具有主要影响，但对合成代谢激素浓度没有影响。总之，急性手术前地塞米松治疗可能通过限制全身性炎症的程度和皮质醇反应而在手术后阶段产生有益的影响。

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