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首页> 外文期刊>Journal of International Medical Research >Psychological reactivity to laboratory stress is associated with hormonal responses in postmenopausal women
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Psychological reactivity to laboratory stress is associated with hormonal responses in postmenopausal women

机译:绝经后妇女对实验室压力的心理反应与激素反应有关

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Objective The present study examined associations between psychological reactivity and hormonal responses to a standardized laboratory stressor (Trier Social Stress Test, TSST) in postmenopausal women. Methods Postmenopausal women aged 50–74 years undertook anxiety and mood assessments prior to and following the TSST. Blood samples were drawn at multiple timepoints for assessment of cortisol, adrenocorticotrophic hormone (ACTH) and dehydroepiandrosterone (DHEA). Results Forty postmenopausal women completed the assessments. As expected, significant increases in anxiety and negative affect and decreases in positive affect were observed after the TSST; however, the magnitude of change in anxiety and mood varied considerably across individuals. Analyses indicated that greater increases in anxiety and negative affect after the TSST were associated with higher levels of cortisol, ACTH and DHEA after controlling for race, age, body mass index and smoking status. Changes in positive affect were not associated with cortisol, ACTH or DHEA. Conclusions These findings suggest that enhanced reactivity to stress is associated with higher hormone levels among postmenopausal women, which could have potential implications for health.
机译:目的本研究探讨了绝经后妇女心理反应与激素对标准化实验室应激源(Trier社会应激测试,TSST)的反应之间的关系。方法年龄在50-74岁的绝经后妇女在TSST前后进行焦虑和情绪评估。在多个时间点抽取血样以评估皮质醇,肾上腺皮质营养激素(ACTH)和脱氢表雄酮(DHEA)。结果40名绝经后妇女完成了评估。如预期的那样,在TSST后观察到焦虑和负面影响显着增加,积极影响减少;但是,焦虑和情绪变化的幅度因人而异。分析表明,在控制种族,年龄,体重指数和吸烟状况之后,TSST后焦虑的增加和负面影响与皮质醇,ACTH和DHEA的升高有关。积极影响的改变与皮质醇,ACTH或DHEA无关。结论这些发现表明,绝经后妇女对压力的反应性增强与激素水平升高有关,这可能对健康产生潜在影响。

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