• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Postmenopausal hormone replacement: effects on autonomic, neuroendocrine, and immune reactivity to brief psychological stressors.
【24h】

Postmenopausal hormone replacement: effects on autonomic, neuroendocrine, and immune reactivity to brief psychological stressors.

机译：绝经后激素替代：对短暂的心理压力对自主神经，神经内分泌和免疫反应的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Postmenopausal status increases some aspects of women's physiological responses to psychological stress; however, the influences of chronic hormone replacement with estrogen and progestogen on these responses are not known. We investigated possible effects of long-term estrogen replacement therapy (ERT), both with and without progestogen, on physiological reactivity to brief laboratory stressors. METHOD: We studied three groups of postmenopausal women: 16 on estrogen alone, 14 on estrogen and progestogen, and 25 control participants receiving no replacement therapy. Cardiovascular, neuroendocrine, and immune data were collected at baseline and after speech and math tasks. RESULTS: In all groups, the stressors reduced vagal cardiac control (indexed by respiratory sinus arrhythmia); increased heart rate and plasma epinephrine, adrenocorticotropic hormone, and cortisol levels; and altered T lymphocyte response (measured by mitogen-induced cell proliferation), natural killer cell lysis, and circulating leukocyte subsets. Women on either type of ERT had higher total cortisol levels (reflecting an estrogen effect on cortisol binding globulin) and greater mitogen-induced blastogenesis across measurement periods than controls. They also showed greater vagal withdrawal and less decline in mitogen-stimulated blastogenesis in response to the stressors. Combined estrogen and progestogen was associated with higher epinephrine and lower circulating total lymphocytes, T cells, and CD4+ T cells across measurement periods, and with intermediate levels of vagal withdrawal in response to the stressors. CONCLUSIONS: Long-term ERT was associated with enhanced parasympathetic responsiveness to stress, suggesting possible reduced demand for potentially detrimental sympathetic activation; and with higher overall levels and smaller stress-induced reductions of mitogen-stimulated blastogenesis, suggesting up-regulated T cell function.
机译：目的：绝经后状态增加了女性对心理压力的生理反应的某些方面。然而，用雌激素和孕激素替代慢性激素对这些反应的影响尚不清楚。我们调查了长期雌激素替代疗法（ERT），无论是否有孕激素，对短暂的实验室应激源的生理反应的可能影响。方法：我们研究了三组绝经后妇女：16例仅接受雌激素，14例接受雌激素和孕激素，25例未接受替代疗法的对照参与者。在基线以及语音和数学任务之后收集心血管，神经内分泌和免疫数据。结果：在所有组中，应激源均降低了迷走性心脏控制（以呼吸窦性心律不齐为指标）。心率和血浆肾上腺素，促肾上腺皮质激素和皮质醇水平升高;并改变了T淋巴细胞反应（通过有丝分裂原诱导的细胞增殖测量），自然杀伤细胞裂解和循环白细胞亚群。与对照组相比，接受任何一种ERT治疗的女性在整个测量期间的总皮质醇水平较高（反映了雌激素对皮质醇结合球蛋白的作用），且丝裂原诱导的胚细胞生成更大。他们还表现出更大的迷走神经退缩和丝裂原刺激的成纤维细胞对应激源的反应减少。在整个测量期间，雌激素和孕激素联合与较高的肾上腺素和较低的循环总淋巴细胞，T细胞和CD4 + T细胞有关，并且与应激反应有关的迷走神经抽出水平中等。结论：长期ERT与对压力的副交感神经反应增强有关，表明对潜在有害的交感神经激活的需求可能减少。总体水平较高，且应力诱导的丝裂原刺激的胚发生减少程度较小，表明T细胞功能上调。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号