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首页> 外文期刊>Journal of Lasers in Medical Sciences >The Combined Effects of Levothyroxine and Low Level Laser Therapy on Wound Healing in Hypothyroidism Male Rat Model
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The Combined Effects of Levothyroxine and Low Level Laser Therapy on Wound Healing in Hypothyroidism Male Rat Model

机译：左甲状腺素和低水平激光疗法对甲状腺功能低下雄性大鼠伤口愈合的联合作用

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Introduction : Hypothyroidism is caused by inadequate production and storage of thyroid hormones. Hypothyroidism is associated with delayed wound healing. Laser therapy may stimulate wound regeneration. The aim of this study was to determine the combined effects of levothyroxine and low level laser therapy during the wound healing process on skin of hypothyroidism male rat model. Methods : Thirty male Wistar rats were randomly divided into 5 groups: control group, hypothyroidism group, hypothyroidism group treated by laser, hypothyroidism group treated by levothyroxine, and hypothyroidism group treated by laser and levothyroxine. To induce hypothyroidism, methimazole was given at a dose of 4 mg/100 mL in their drinking water. After hypothyroidism was proven through immunoassay commercial kit, rats were generally anesthetized with ketamine and xylazine, then, an incisional skin wound was created in a length of 1.2 cm on the back of the ribcage. The surgical day is considered as the zero day. The third and fifth groups were treated with a pulse laser, 810 nm wavelength 80 Hz frequency and 0.2 J/cm2 energy densities for 200 seconds. Levothyroxine was injected to the fourth and fifth groups intraperitoneally. On the 14th day, a normal sample of each healing skin wound was harvested for biomechanical examination. The obtained data were analyzed by the SPSS software 21 and reported as a mean ± standard error of mean (SEM). P & 0.05 was considered statistically significant. Results : The results showed that the mean maximum force and the accomplished work (energy) made a significant difference in the group receiving both laser and levothyroxine synchronously rather than the other groups (P ≤ 0.05). The elasticity of the wound healing in the groups that received laser and levothyroxine synchronously was significantly higher in comparison with the control and hypothyroidism groups but the difference was not significant in comparison with the laser or levothyroxine groups. Conclusion : The results of our study showed that the application of laser and levothyroxine synchronously improves the biomechanical parameters of wound during healing in comparison to the use of laser and levothyroxine solely
机译：简介：甲状腺功能减退是由甲状腺激素的生产和储存不足引起的。甲状腺功能减退症与伤口愈合延迟有关。激光疗法可能会刺激伤口再生。这项研究的目的是确定在甲状腺功能减退症雄性大鼠皮肤伤口愈合过程中左甲状腺素和低水平激光疗法的联合作用。方法：雄性Wistar大鼠30只，随机分为5组：对照组，甲状腺功能减退组，激光治疗甲状腺功能减退组，左甲状腺素治疗甲状腺功能减退组，激光和左甲状腺素治疗甲状腺功能减退组。为了诱发甲状腺功能减退症，在他们的饮用水中以4 mg / 100 mL的剂量服用甲他唑。通过免疫测定商业试剂盒证实甲状腺功能减退后，一般用氯胺酮和甲苯噻嗪麻醉大鼠，然后在胸腔背面长1.2厘米，切开皮肤切口。手术日被视为零日。第三组和第五组用脉冲激光，810 nm波长，80 Hz频率和0.2 J / cm2的能量密度处理200秒。左甲状腺素被腹膜内注射到第四和第五组。在第14天，收获每个愈合的皮肤伤口的正常样品以进行生物力学检查。所获得的数据通过SPSS软件21进行分析，并以平均值±平均值的标准误差（SEM）报告。 P ＜ 0.05被认为具有统计学意义。结果：结果表明，在同时接受激光和左甲状腺素治疗的组中，平均最大力量和完成的功（能量）有显着差异（P≤0.05）。与对照组和甲状腺功能减退组相比，同步接受激光和左甲状腺素治疗组的伤口愈合弹性显着更高，但与激光或左甲状腺素组相比，差异不显着。结论：我们的研究结果表明，与仅使用激光和左甲状腺素相比，激光和左甲状腺素的应用同步改善了伤口在愈合过程中的生物力学参数。

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