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首页> 外文期刊>Journal of Lasers in Medical Sciences >Comparison of the Antimicrobial Efficacy of Calcium Hydroxide and Photodynamic Therapy Against Enterococcus faecalis and Candida albicans in Teeth With Periapical Lesions; An In Vivo Study
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Comparison of the Antimicrobial Efficacy of Calcium Hydroxide and Photodynamic Therapy Against Enterococcus faecalis and Candida albicans in Teeth With Periapical Lesions; An In Vivo Study

机译：氢氧化钙的抗菌作用比较及光动力疗法对根尖病变的粪肠球菌和白色念珠菌的治疗;体内研究

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Introduction: Elimination of pathological microflora of root canal systems is a major goal in endodontic treatment. This study aimed to compare the antimicrobial efficacy of calcium hydroxide as an intracanal medication and antibacterial photodynamic therapy (aPDT) against Enterococcus faecalis and Candida albicans in teeth with periapical (PA) lesions. Methods: This in vivo study was conducted on 20 patients with single-rooted mandibular premolar with previously failed endodontic treatment. This study was performed as a clinical trial (IRCTID: IRCT2016090429686N1). After conventional chemo-mechanical root canal preparation (hand and rotary instruments and 2.5% NaOCl), microbiological samples were obtained using sterile paper points, then stored in thioglycolate solution and transferred to a microbiology laboratory. Group 1 (n = 10) specimens underwent aPDT (diode laser 808 nm + 50 mg/mL methylene blue), while creamy calcium hydroxide paste was used in group 2 for a duration of 1 week. A control sample was taken with sterile paper points and F3 Protaper rotary file. The samples were dispersed in transport medium, serially diluted, and cultured on selective mediums to determine the number of colony forming units (CFUs). Data were analyzed by Mann-Whitney U test at 5% significance level. The significance level for all analyses was set at P &0.05. Results: Number of CFU significantly decreased in both groups after the interventions ( P &0.001); however, there was no significant difference in the colony count between the 2 groups. Conclusion: aPDT and calcium hydroxide therapy showed the same antimicrobial efficacy on E. faecalis and C. albicans .
机译：简介：消除根管系统的病理菌群是牙髓治疗的主要目标。这项研究旨在比较氢氧化钙作为根管内药物和抗菌光动力疗法（aPDT）对根尖周炎（PA）病变牙齿中的粪肠球菌和白色念珠菌的抗菌功效。方法：这项体内研究是针对20例单牙根下颌前磨牙患者，之前曾进行过牙髓治疗失败。这项研究是作为一项临床试验进行的（IRCTID：IRCT2016090429686N1）。在常规的化学机械根管制备（手动和旋转器械以及2.5％NaOCl）之后，使用无菌纸尖获得微生物样品，然后将其保存在巯基乙酸盐溶液中，并转移至微生物实验室。第1组（n = 10）的标本进行了aPDT（二极管激光808 nm + 50 mg / mL亚甲蓝），而第2组中使用了乳状氢氧化钙糊剂，持续了1周。用无菌纸尖和F3 Protaper旋转锉取样作为对照样品。将样品分散在运输培养基中，连续稀释，并在选择性培养基上培养以确定菌落形成单位（CFU）的数量。通过Mann-Whitney U检验以5％的显着性水平分析数据。所有分析的显着性水平设定为P ＜0.05。结果：干预后两组的CFU数量均显着下降（P ＜0.001）;然而，两组之间的菌落数没有显着差异。结论：aPDT和氢氧化钙治疗对粪肠球菌和白色念珠菌具有相同的抗菌作用。

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