...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of International Medical Research >Autoradiographic Localization and Computerized Quantification of α1- and α2-Adrenoceptors in Spontaneously Hypertensive Rat Kidney: [3H]Bunazosin and [3H]Yohimbine Binding Studies
【24h】

Autoradiographic Localization and Computerized Quantification of α1- and α2-Adrenoceptors in Spontaneously Hypertensive Rat Kidney: [3H]Bunazosin and [3H]Yohimbine Binding Studies

机译：自发性高血压大鼠肾脏中α1-和α2-肾上腺素受体的放射自显影定位和计算机定量：[3H]苯并唑嗪和[3H]育亨宾结合研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The autoradiographic localization of α1- and α2-adrenoceptors was identified in 22-week-old Wistar – Kyoto rat kidney, using α1-selective ([3H]bunazosin) and α2-selective ([3H]yohimbine) antagonists. [3H]Bunazosin binding was distributed predominantly over the cortex, less over the outer medulla and was absent from the inner medulla. [3H]Yohimbine binding was distributed predominantly over the medulla, less over the renal cortex and was absent from the inner medulla. In addition, the distribution of renal α-adrenoceptors was investigated in 3-, 7- and 22-week-old spontaneously hypertensive rats (SHRs) using a computerized image analysis system. Renal α-adrenoceptors were both found to be increased in SHRs at all ages tested compared with their respective controls and were increased in both the cortex and the outer medulla. The increase in renal α-adrenoceptors was already present in 3-week-old SHRs whose systolic blood pressures did not differ significantly from those of the controls. The results strongly suggest that these abnormalities of renal α-adrenoceptors may play a critical role in the development of hypertension in SHRs.
机译：在22周大的Wistar – Kyoto大鼠肾脏中，使用α1选择性（[3H] bunazosin）和α2选择性（[3H] yohimbine）拮抗剂确定了α1-和α2-肾上腺素受体的放射自显影定位。 [3H]布纳唑嗪结合主要分布在皮质上，较少分布在外延髓上，而在内延髓不存在。 [3H]育亨宾结合主要分布在髓质上，较少分布在肾皮质上，而内髓质则不存在。此外，使用计算机图像分析系统在3、7和22周龄自发性高血压大鼠（SHRs）中研究了肾α-肾上腺素受体的分布。肾α-肾上腺素能受体在所有年龄的受试患者中均与对照相比均升高，在皮质和髓质外均升高。肾α-肾上腺素受体的增加已经存在于3周龄的SHR中，其收缩压与对照组无明显差异。这些结果强烈表明，这些肾脏α-肾上腺素受体异常可能在SHRs高血压的发展中起关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号