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首页> 外文期刊>Journal of International Medical Research >A Randomized, Double-Blind Trial of Palonosetron Compared with Ondansetron in Preventing Postoperative Nausea and Vomiting after Gynaecological Laparoscopic Surgery
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A Randomized, Double-Blind Trial of Palonosetron Compared with Ondansetron in Preventing Postoperative Nausea and Vomiting after Gynaecological Laparoscopic Surgery

机译：帕洛诺司琼与恩丹西酮比较的随机，双盲试验在预防妇科腹腔镜手术后恶心和呕吐中的作用

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This randomized, double-blind study evaluated the relative efficacy of palonosetron (a new, selective 5-hydroxytryptamine type 3 [5-HT3] receptor antagonist) and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing gynaecological laparoscopic surgery. Patients received either palonosetron 0.075 mg (n = 45) or ondansetron 8 mg (n = 45), intravenously, immediately before induction of general anaesthesia. The occurrence of nausea and vomiting and the severity of nausea according to a visual analogue scale were monitored immediately after the end of surgery and during the following 24 h. The incidence of PONV was significantly lower in the palonosetron group compared with the ondansetron group (42.2% vs 66.7%, respectively). There were no significant statistical differences in the visual analogue scale for nausea. In conclusion, palonosetron 0.075 mg was more effective than ondansetron 8 mg in preventing PONV.
机译：这项随机，双盲研究评估了帕洛诺司琼（一种新型的选择性5羟色胺3型[5-HT3]受体拮抗剂）和恩丹西酮在妇科腹腔镜手术患者中预防术后恶心和呕吐（PONV）的相对疗效。患者在全身麻醉前即刻静脉接受帕洛诺司琼0.075 mg（n = 45）或恩丹西酮8 mg（n = 45）。在手术结束后和随后的24小时内，立即按照视觉模拟量表监测恶心和呕吐的发生以及恶心的严重程度。与奥丹西酮组相比，帕洛诺司琼组PONV的发生率明显更低（分别为42.2％和66.7％）。视觉模拟评分表对恶心没有显着统计学差异。总之，帕洛诺司琼0.075 mg在预防PONV方面比昂丹司琼8 mg更有效。

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