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首页> 外文期刊>Journal of Indian Society of Periodontology >Immunohistological analysis of CD1a+ langerhans cells and CD57+ natural killer cells in healthy and diseased human gingival tissue: A comparative study
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Immunohistological analysis of CD1a+ langerhans cells and CD57+ natural killer cells in healthy and diseased human gingival tissue: A comparative study

机译：健康和患病人牙龈组织中CD1a + Langerhans细胞和CD57 +自然杀伤细胞的免疫组织学分析：对比研究

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Background:Cell interaction between dendritic cells (DC) and natural killer (NK) cells in the periodontal milieu is not yet fully known, although these cells are individually known to contribute to the pathogenesis of periodontal disease.Materials and Methods:Fifty subjects (25 males and 25 females) were included in the study. The subjects were divided into three groups: Group A comprised 16 subjects with clinically healthy gingiva; group B 17 subjects with gingivitis; and group C 17 subjects with gingivitis; and group C 17 subjects with moderate periodontitis (PPD ≥ 5 mm and CAL ≥ 3 mm in at least six sites). Gingival samples were collected and immunohistochemical study was done using CD57 and CD1a antibody. Statistical analysis was done using analysis of variance (ANOVA), followed by Tukey-Kramer multiple comparison for CD1a and Tukey's highly significant difference (HSD) test for CD57.Results and Conclusion:The study showed an inverse relationship between the CD1a+ (langerhans) cells and CD57+ (natural killer) cells. There was a significant increase in CD57+ cells and reduction in CD1a levels as periodontal disease progressed. The significant reduction in CD1a levels in periodontal disease when compared to health could possibly be a result of NK cells down regulating it. Reduction in CD1a levels may result in a low inflammatory response subsequently resulting in tissue destruction.
机译：背景：虽然众所周知，树突状细胞（DC）和自然杀伤（NK）细胞在牙周环境中的细胞相互作用尚不完全清楚，但这些细胞单独导致牙周疾病的发病机理也有研究。材料与方法：五十名受试者（25男性和25名女性）被纳入研究。将受试者分为三组：A组包括16名临床健康牙龈的受试者; B组17例患有牙龈炎的受试者; C组17名患有牙龈炎的受试者; C组17名患有中度牙周炎的受试者（至少六个部位的PPD≥5 mm，CAL≥3 mm）。收集牙龈样品，并使用CD57和CD1a抗体进行免疫组织化学研究。使用方差分析（ANOVA）进行统计分析，然后对CD1a进行Tukey-Kramer多重比较，对CD57进行Tukey的高显着性差异（HSD）检验。和CD57 +（自然杀手）细胞。随着牙周疾病的进展，CD57 +细胞显着增加，CD1a水平降低。与健康相比，牙周疾病CD1a水平的显着降低可能是NK细胞下调CD1a水平的结果。 CD1a水平的降低可能导致较低的炎症反应，继而导致组织破坏。

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