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首页> 外文期刊>Journal of Lasers in Medical Sciences >The Disinfecting Efficacy of Root Canals with Laser Photodynamic Therapy
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The Disinfecting Efficacy of Root Canals with Laser Photodynamic Therapy

机译：激光光动力疗法对根管的消毒效果

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Introduction: Infecting microorganisms of the root canals are difficult to eliminate during endodontic treatment. In this study the effect of root canal disinfection with photodynamic therapy (PDT) at different time intervals in comparison to 2.5% sodium hypochlorite (NaOCl) irrigation and passive ultrasonic irrigation (PUI) in extracted teeth colonized with Enterococcus faecalis and Candida albicans was tested to assess which treatment reaches the best disinfection rate. Methods: One hundred and fifty-six extracted single-rooted teeth were collected, sterilized, and incubated with Enterococcus faecalis (ATCC 29212) and Candida albicans (ATCC 60193). The two groups were further divided into 6 groups depending on the treatment mode; HELBO?Endo Blue photosensitizer dye application followed by HELBO laser irradiation, with the output power 100 mW and emission of 660 nm, for a 1, 3 and 5 minutes, irrigation with 2.5% NaOCl, 10 second PUI with 2.5% NaOCl and control group. Flow cytometry and scanning electron microscopic (SEM) analysis were used to determine the effectiveness of the different disinfecting methods. Results: The different disinfecting methods had a significantly different effect on the percent of dead cells (p&0.001). A statistical significance of dead cells between organisms (p&0.001) was observed. Interaction between the disinfecting method and both of organisms had shown the statistical significance (p=0.045). Percent of dead cells in treatment groups were significantly higher compared to control group for both organisms (p&0.001). Conclusions: PUI still remains the most effective method for disinfection of infected root canalsin endodontics compared to hand instrumentation for both microorganisms. SEM analysis only confirmed the results. Other results ex vivo suggested that prolonging the time from 1 to 5 minutes of PDT increased the number of killed microorganisms significantly, therefore longer times of photodynamic therapy were recommended. Irrigation with 2.5% NaOCl showed similar results to 5 min irradiation.
机译：简介：根管治疗过程中很难消除感染根管的微生物。在这项研究中，通过光动力疗法（PDT）在不同时间间隔与2.5％次氯酸钠（NaOCl）冲洗和被动超声冲洗（PUI）相比，对粪肠球菌和白色念珠菌定植的拔牙效果进行了测试，评估哪种治疗达到最佳消毒率。方法：收集一百五十六颗拔出的单根牙齿，进行消毒，然后与粪肠球菌（ATCC 29212）和白色念珠菌（ATCC 60193）一起孵育。根据治疗方式将两组进一步分为6组。使用HELBO？Endo Blue光敏剂染料，然后进行HELBO激光辐照，输出功率100 mW，发射660 nm，持续1、3和5分钟，分别用2.5％NaOCl，10秒PUI和2.5％NaOCl冲洗，对照组。流式细胞仪和扫描电子显微镜（SEM）分析用于确定不同消毒方法的有效性。结果：不同的消毒方法对死细胞的百分比具有显着不同的影响（p ＜0.001）。观察到生物之间死细胞的统计显着性（p ＜0.001）。消毒方法与两种生物之间的相互作用显示出统计学意义（p = 0.045）。对于两种生物，治疗组中死细胞的百分比均显着高于对照组（p ＜0.001）。结论：与手工器械相比，PUI仍然是牙髓学中感染根管消毒的最有效方法。 SEM分析仅证实了结果。离体的其他结果表明，PDT时间从1分钟延长到5分钟会显着增加被杀死微生物的数量，因此建议使用更长的光动力疗法时间。用2.5％NaOCl灌溉显示出与5分钟辐照相似的结果。

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