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首页> 外文期刊>Journal of International Medical Research >Expression of c-erbB-2 and p53 in Breast Carcinoma Patients: Comparison with Traditional Prognostic Factors and Survival
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Expression of c-erbB-2 and p53 in Breast Carcinoma Patients: Comparison with Traditional Prognostic Factors and Survival

机译：乳腺癌患者中c-erbB-2和p53的表达：与传统预后因素和生存率的比较

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摘要

We aimed to determine the correlations between standard clinicopathological factors and expression of c-erbB-2 and p53 proteins, and to investigate the significance of these variables in relapse and disease-free survival (DFS) in breast carcinoma patients. Data from 200 patients who had undergone mastectomy for breast carcinoma were evaluated. Significant correlations were found between c-erbB-2 positivity and high histological grade (grade 3) tumour, p53 positivity and high grade tumour, and age < 60 years and oestrogen receptor negativity. Twenty-six patients (13%) developed a recurrence. Disease relapse was more frequent in patients who had axillary lymph node (ALN) metastasis, high grade tumour, c-erbB-2 positivity and p53 positivity; these variables were also associated with a shorter DFS. The effects of ALN metastasis and p53 positivity were significant. In conclusion, ALN metastasis and p53 positivity were important factors for predicting disease relapse in mastectomy-treated breast carcinoma patients; other clinicopathological criteria and c-erbB-2 positivity were not predictive.
机译：我们旨在确定标准临床病理因素与c-erbB-2和p53蛋白表达之间的相关性，并研究这些变量在乳腺癌患者复发和无病生存期（DFS）中的意义。评价了来自200例接受乳房切除术的乳腺癌患者的数据。发现c-erbB-2阳性与高组织学等级（3级）肿瘤，p53阳性和高等级肿瘤，年龄<60岁和雌激素受体阴性之间存在显着相关性。 26位患者（13％）复发。腋窝淋巴结转移，高级别肿瘤，c-erbB-2阳性和p53阳性的患者疾病复发更为频繁。这些变量还与较短的DFS相关。 ALN转移和p53阳性的影响是显着的。总之，ALN转移和p53阳性是预测乳房切除术治疗的乳腺癌患者疾病复发的重要因素。其他临床病理学标准和c-erbB-2阳性均不能预测。

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