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首页> 外文期刊>Journal of International Medical Research >Nicardipine versus Nitroprusside Infusion as Antihypertensive Therapy in Hypertensive Emergencies
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Nicardipine versus Nitroprusside Infusion as Antihypertensive Therapy in Hypertensive Emergencies

机译：尼卡地平vs硝普钠输注作为高血压紧急情况的降压治疗

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摘要

This prospective study compared the efficacy of nicardipine and nitroprusside for treating hypertensive emergencies by measuring haemodynamic indices and serum catecholamine levels. Patients admitted to the emergency department with a hypertensive crisis and acute pulmonary oedema received intravenous infusions of nitroprusside (starting dose 1 μg/kg per min, n = 20) or nicardipine (starting dose 3 μg/kg per min, n = 20). Both groups experienced significant declines in systolic and diastolic blood pressure after treatment, but there were no significant time-dependent differences between the groups. Heart rate decreased in the nicardipine group and increased in the nitroprusside group, but neither change was significant. Respiration rate decreased and capillary oxygen saturation rate increased after treatment in both groups. Adrenaline and noradrenaline levels decreased significantly after treatment in both groups; noradrenaline levels were significantly decreased in the nicardipine-treated group compared with the nitroprusside-treated group. Injectable nicardipine is easy to use and as effective as nitroprusside for treating hypertensive crisis with acute pulmonary oedema.
机译：这项前瞻性研究通过测量血流动力学指数和血清儿茶酚胺水平，比较了尼卡地平和硝普钠治疗高血压急症的疗效。进入急诊科并患有高血压危机和急性肺水肿的患者接受了硝普钠（起始剂量1μg/ kg / min，n = 20）或尼卡地平（起始剂量3μg/ kg / min，n = 20）的静脉输注。两组治疗后收缩压和舒张压均明显下降，但两组之间无明显的时间依赖性。尼卡地平组心率下降，硝普钠组心率上升，但变化均无统计学意义。两组治疗后呼吸频率下降，毛细血管血氧饱和度上升。两组治疗后肾上腺素和去甲肾上腺素水平均显着下降。与硝普钠治疗组相比，尼卡地平治疗组的去甲肾上腺素水平显着降低。尼卡地平注射剂易于使用，与硝普钠一样有效，可治疗急性肺水肿的高血压病。

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