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首页> 外文期刊>Journal of International Medical Research >A Comparison of Dothiepin versus Placebo in the Treatment of Pain in Rheumatoid Arthritis and the Association of Pain with Depression
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A Comparison of Dothiepin versus Placebo in the Treatment of Pain in Rheumatoid Arthritis and the Association of Pain with Depression

机译：多西平与安慰剂治疗类风湿关节炎疼痛及疼痛与抑郁症的关系比较

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摘要

The effectiveness of dothiepin (a tricyclic anti-depressant) at a dose of 75 mg given orally at night was compared with placebo for 4 weeks in alleviating pain in 60 patients with classical or definite active rheumatoid arthritis. Patients were classified as either ‘depressed’ or ‘not depressed’. The week before, during and 2 weeks after the study, 600 mg ibuprofen was given orally three times daily to all patients. Compared with placebo, dothiepin produced a significant reduction in daytime pain by the end of the treatment period. The Hamilton rating scale in ‘depressed’ patients was significantly improved in patients given dothiepin. The Cassano–Castrogiovanni self-evaluation rating scale in both ‘depressed’ and ‘not depressed’ patients showed a tendency (not significant) to be improved following dothiepin treatment compared with placebo. These results suggest that patients with rheumatoid arthritis may experience an increase in pain symptoms due to an alteration of mood. Therapy with tricyclic anti-depressants, such as dothiepin, therefore, may determine an improvement of pain indexes besides having an anti-depressant effect.
机译：在60例经典或确定性活动性类风湿关节炎患者中，在夜间口服多西平（三环类抗抑郁药）75毫克的效果与安慰剂进行了4周的缓解效果比较。患者被分为“沮丧”或“未沮丧”。在研究前，研究中和研究后2周，每天对所有患者口服3次600 mg布洛芬。与安慰剂相比，多西平在治疗期结束时可使白天的疼痛明显减轻。接受多西平治疗的患者在“抑郁症”患者中的汉密尔顿评定量表得到了显着改善。与安慰剂相比，多西平治疗后的“抑郁”和“未抑郁”患者的卡萨诺-卡斯特罗焦尼自我评估等级量表都有改善的趋势（不明显）。这些结果表明类风湿关节炎患者可能会由于情绪变化而出现疼痛症状增加。因此，除了具有抗抑郁作用外，用三环抗抑郁药例如多西平治疗还可以确定疼痛指数的改善。

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