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首页> 外文期刊>Journal of International Medical Research >Scavenger Effect of Elastase on Calcifications in Liver, Kidney and Central Nervous System Tissues of Rabbits with Atherosclerosis Induced by Cholesterol-Rich Diet
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Scavenger Effect of Elastase on Calcifications in Liver, Kidney and Central Nervous System Tissues of Rabbits with Atherosclerosis Induced by Cholesterol-Rich Diet

机译：弹性蛋白酶对高胆固醇饮食致兔动脉粥样硬化兔肝脏，肾脏和中枢神经系统钙化的清除作用

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The inhibitory effect of elastase on calcification in liver, kidney and the central nervous system (CNS) was studied in rabbits with atherosclerosis induced by a cholesterol-rich diet. A total of 25 male rabbits were divided into six groups. In the first three groups, rabbits received a standard diet, a 1.5% cholesterol-rich diet or a 1.5% cholesterol-rich diet with intraperitoneal elastase (450 IU/kg·day) for 3 months. In the second three groups, rabbits received a standard diet, a 0.67% cholesterol-rich diet or a 0.67% cholesterol-rich diet with intraperitoneal elastase (450 IU/kg day) for 6 months. Tissue calcium levels were then determined by neutron activation analysis. Tissue lipid levels were also measured. Dietary cholesterol increased serum lipid levels, atherosclerotic lesions and calcium levels in the CNS, but not in the liver or kidney. Calcium levels in the cerebellum and spinal cord of rabbits receiving the 0.67% cholesterol-rich diet plus elastase were significantly lower than those of rabbits receiving the 0.67% cholesterol diet alone. Elastase had a gradual inhibitory effect on the increase in calcium levels in CNS of cholesterol-induced atherosclerotic rabbits, reduced the increase in serum lipids and decreased the incidence of atherosclerotic lesions.
机译：在富含胆固醇饮食引起的动脉粥样硬化兔中，研究了弹性蛋白酶对肝脏，肾脏和中枢神经系统（CNS）钙化的抑制作用。总共25只雄性兔子被分成六组。在前三组中，兔子接受标准饮食，1.5％的高胆固醇饮食或1.5％的高胆固醇饮食以及腹膜内弹性蛋白酶治疗（450 IU / kg·天），持续3个月。在后三组中，兔子接受标准饮食，0.67％的高胆固醇饮食或0.67％的高胆固醇饮食以及腹膜内弹性蛋白酶治疗（450 IU / kg天），为期6个月。然后通过中子活化分析确定组织钙水平。还测量了组织脂质水平。膳食胆固醇会增加中枢神经系统（而非肝脏或肾脏）的​​血脂水平，动脉粥样硬化病变和钙水平。接受0.67％高胆固醇饮食加弹性蛋白酶的兔子的小脑和脊髓中的钙水平显着低于单独接受0.67％胆固醇饮食的兔子。弹性蛋白酶对胆固醇诱导的动脉粥样硬化兔的中枢神经系统中钙水平的升高具有逐渐的抑制作用，降低了血脂的升高，并降低了动脉粥样硬化病变的发生率。

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