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首页> 外文期刊>Journal of International Medical Research >A Comparison between the Efficacy of Ketotifen and Clemastine in Children
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A Comparison between the Efficacy of Ketotifen and Clemastine in Children

机译：酮替芬和卡马斯汀对儿童的疗效比较

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In a controlled single-blind study of 12 weeks' duration the prophylactic antiasthmatic effects of ketotifen and clemastine in children with bronchial asthma were compared. The drugs were administered in syrup form in doses from 1 to 2 mg per day according to the body-weight. Fifty-seven children, twenty-nine in the ketotifen group and twenty-eight in the clemastine group took part. The clinical parameters, namely asthmatic complaints, dyspnoea and total duration of asthmatic attacks initially improved with both drugs but only with ketotifen was there a further marked benefit leading to a significant superiority of this drug over clemastine in the 8th and 12th week of treatment. In the overall assessment ketotifen was considered to be very effective and effective in 83% of the patients, clemastine was considered to be very effective and effective in 29%. Both drugs were well tolerated.
机译：在一项为期12周的对照单盲研究中，比较了酮替芬和clemastine对支气管哮喘患儿的预防性抗哮喘作用。根据体重，药物以糖浆形式给药，每天剂量为1至2 mg。共有57名儿童，其中酮替芬组29名儿童和clemastine组28名儿童参加了比赛。两种药物最初改善了临床参数，即哮喘主诉，呼吸困难和哮喘发作的总持续时间，但仅使用酮替芬才有进一步显着的获益，导致该药物在治疗的第8周和第12周显着优于clemastine。在总体评估中，酮替芬被认为对83％的患者非常有效，克里马汀被认为对29％的患者非常有效。两种药物均耐受良好。

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