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首页> 外文期刊>Journal of International Medical Research >Serum levels of thyroid hormones and thyroid stimulating hormone in patients with biliogenic and hyperlipidaemic acute pancreatitis: Difference and value in predicting disease severity
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Serum levels of thyroid hormones and thyroid stimulating hormone in patients with biliogenic and hyperlipidaemic acute pancreatitis: Difference and value in predicting disease severity

机译：胆源性和高脂血症性急性胰腺炎患者的血清甲状腺激素和促甲状腺激素水平：预测疾病严重程度的差异和价值

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Objectives To compare retrospectively serum levels of thyroid hormones (THs) and thyroid stimulating hormone (TSH) between patients with biliogenic acute pancreatitis (BAP) and those with hyperlipidaemic acute pancreatitis (HLAP), in order to assess their value for predicting the severity of acute pancreatitis (AP). Methods Patients with AP were divided into BAP and HLAP groups, then further divided into either a mild AP (MAP) group or a moderately severe AP (MSAP) group. Routine blood parameters were measured. Free tri-iodothyronine (FT3), free thyroxine (FT4) and TSH levels were measured. Results Seventy-six patients with AP were enrolled in the study. FT3 and TSH levels were significantly higher in patients with MAP than in patients with MSAP. FT4 and TSH levels were significantly lower in the HLAP group than in the BAP group. TSH levels in both MAP and MSAP patients were significantly lower in the HLAP group than in the BAP group. TSH was inversely correlated with triglyceride levels in patients with HLAP. FT3 was a risk factor for MSAP in patients with AP and also demonstrated moderate accuracy in predicting AP severity. Conclusions THs and TSH decrease with the severity of AP, especially in patients with HLAP. FT3 may be a useful biomarker for the early assessment of the severity of AP.
机译：目的回顾性比较胆源性急性胰腺炎（BAP）和高脂血症性急性胰腺炎（HLAP）患者的甲状腺激素（THs）和甲状腺刺激激素（TSH）的血清水平，以评估其对预测急性严重程度的价值胰腺炎（AP）。方法将AP患者分为BAP组和HLAP组，然后进一步分为轻度AP（MAP）组或中度重度AP（MSAP）组。测量了常规血液参数。测量游离的三碘甲状腺素（FT3），游离甲状腺素（FT4）和TSH水平。结果共纳入76例AP患者。 MAP患者的FT3和TSH水平显着高于MSAP患者。 HLAP组的FT4和TSH水平显着低于BAP组。 HLAP组的MAP和MSAP患者的TSH水平均显着低于BAP组。 HLAP患者的TSH与甘油三酸酯水平呈负相关。 FT3是AP患者MSAP的危险因素，并且在预测AP严重程度方面也显示出中等准确性。结论TH和TSH随AP严重程度而降低，尤其是HLAP患者。 FT3可能是早期评估AP严重程度的有用生物标志物。

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