Enhanced Effect of Clarithromycin on Neutrophil Function In Vitro

H Akamatsu; Y Niwa; H Sasaki; Y Asada; T Horio

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Enhanced Effect of Clarithromycin on Neutrophil Function In Vitro

机译：克拉霉素对中性粒细胞功能的增强作用

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An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated 02?, H202 and OH· levels were significantly increased by clarithromycin at concentrations of 50 μg/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.

机译：进行了一项体外研究，研究了一种新的口服大环内酯类克拉霉素对中性粒细胞活性氧的产生和趋化性的影响。发现在浓度为50μg/ ml的克拉霉素中，中性粒细胞生成的02α，H2O2和OH·的水平显着增加（P <0.05）。该药物还显着增加趋化性（P <0.05）。这些结果表明克拉霉素可以增强体内嗜中性粒细胞的活化。

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《Journal of International Medical Research》 |1996年第2期|共5页
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H Akamatsu; Y Niwa; H Sasaki; Y Asada; T Horio;
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中图分类药学;
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6. Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin its major metabolite in humans. [O] . D J Hardy, R N Swanson, R A Rode, 1990

机译：14-羟基-克拉霉素它是人类的主要代谢产物可增强克拉霉素抗流感嗜血杆菌的体外和体内活性。
7. Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its major metabolite in humans. [O] . Hardy, D J, Swanson, R N, Rode, R A, 1990

机译：14-羟基-克拉霉素，它是人类的主要代谢产物，可增强克拉霉素抗流感嗜血杆菌的体外和体内活性。

Enhanced Effect of Clarithromycin on Neutrophil Function In Vitro

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