A Comparative Study on the Safety and Efficacy of Tamsulosin and Alfuzosin in the Management of Symptomatic Benign Prostatic Hyperplasia: A Randomized Controlled Clinical Trial

MCM Lapitan; V Acepcion; J Mangubat

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A Comparative Study on the Safety and Efficacy of Tamsulosin and Alfuzosin in the Management of Symptomatic Benign Prostatic Hyperplasia: A Randomized Controlled Clinical Trial

机译：坦索罗辛和阿夫唑嗪治疗有症状的良性前列腺增生的安全性和有效性的比较研究：随机对照临床试验。

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This randomized, double-blind, parallel-design trial compared the efficacy and safety of tamsulosin and alfuzosin in 76 men with symptomatic benign prostatic hyperplasia. Patients were randomized to receive 0.2 mg tamsulosin once daily orally (n = 40) or 10 mg alfuzosin once daily orally (n = 36), and changes in the International Prostate Symptom Score (IPSS), maximal urinary flow rate (Qmax) and the Danish prostatic symptom sexual function score and morbidity rates were compared after 8 weeks of treatment. There was a mean overall decrease in the IPSS, with no significant difference between the treatment groups. There was an overall increase in the Qmax, which again was similar in the two groups. There was no significant change in the sexual function scores in either group. The incidence of adverse events was similar for tamsulosin (25%) and alfuzosin (19.4%) therapy. In conclusion, both treatment regimens similarly improved the IPSS and Qmax, did not alter sexual function and were well tolerated.

机译：这项随机，双盲，平行设计的试验比较了坦索罗辛和阿夫唑嗪对76例有症状的良性前列腺增生男性的疗效和安全性。患者被随机分配为每天口服0.2 mg坦索罗辛（n = 40）或每天口服10 mg阿夫唑嗪（n = 36），并根据国际前列腺症状评分（IPSS），最大尿流率（Qmax）和治疗8周后比较丹麦前列腺症状性功能评分和发病率。 IPSS总体平均下降，各治疗组之间无显着差异。 Qmax总体上有所增加，两组再次相似。两组的性功能评分均无明显变化。坦索罗辛（25％）和阿夫唑嗪（19.4％）治疗的不良事件发生率相似。总之，两种治疗方案均可以改善IPSS和Qmax，不改变性功能且耐受性良好。

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《Journal of International Medical Research》 |2005年第5期|共12页
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MCM Lapitan; V Acepcion; J Mangubat;
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6. Efficacy and Safety of Medium-to-long-term Use of Tolterodine Extended Release with or without Tamsulosin in Patients with Benign Prostate Hyperplasia and Larger Prostate Size: A Double-blind Placebo-controlled Randomized Clinical Trial [O] . Jian-Liang Cai, Zhe Zhou, Yan Yang, 2016

机译：良性前列腺增生和前列腺较大患者中长期使用托特罗定缓释联合或不联合坦索罗辛的疗效和安全性：双盲安慰剂对照随机临床试验
7. Efficacy and Safety of Medium-to-long-term Use of Tolterodine Extended Release with or without Tamsulosin in Patients with Benign Prostate Hyperplasia and Larger Prostate Size: A Double-blind, Placebo-controlled, Randomized Clinical Trial [O] . Jian-Liang Cai, Zhe Zhou, Yan Yang, 2016

机译：中，长期使用Tolterodine延长释放与或不与坦索罗辛治疗良性前列腺增生和前列腺大的患者的疗效和安全性：双盲，安慰剂对照，随机临床试验

A Comparative Study on the Safety and Efficacy of Tamsulosin and Alfuzosin in the Management of Symptomatic Benign Prostatic Hyperplasia: A Randomized Controlled Clinical Trial

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